3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid

Base Information

Chemical Name:3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid
CAS No.:1000587-43-8
Molecular Formula:C₁₄H₁₁N₅O₂
Molecular Weight:281.274
Hs Code.:

Synonyms:3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid

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Chemical Property of 3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid

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Technology Process of 3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid

There total 7 articles about 3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1000587-42-7
3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid methyl ester

: 1000587-43-8
3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid

Guidance literature:: 3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 0 - 20 ℃;

With hydrogenchloride; water; at 20 ℃; pH=6 - 7;

Reference yield:

: 121-92-6
3-nitrobenzoic acid

: 1000587-43-8
3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: iodine; sulfuric acid / 14 h / 85 °C

2: thionyl chloride / 2 h / 0 °C / Reflux

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,2-dimethoxyethane / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

5: methanol; tin(ll) chloride / 3 h / Reflux

6: sodium azide; acetic acid / 3 h / Reflux

7: lithium hydroxide; water / tetrahydrofuran / 0 - 20 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium azide; sulfuric acid; water; iodine; potassium acetate; acetic acid; tin(ll) chloride; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; dimethyl sulfoxide;

Reference yield:

: 6313-17-3
3-iodo-5-nitro-benzoic acid

: 1000587-43-8
3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 2 h / 0 °C / Reflux

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,2-dimethoxyethane / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

4: methanol; tin(ll) chloride / 3 h / Reflux

5: sodium azide; acetic acid / 3 h / Reflux

6: lithium hydroxide; water / tetrahydrofuran / 0 - 20 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium azide; water; potassium acetate; acetic acid; tin(ll) chloride; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; dimethyl sulfoxide;