1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol

Base Information

Chemical Name:1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol
CAS No.:403857-07-8
Molecular Formula:C₁₉H₃₄O₄Si
Molecular Weight:354.562
Hs Code.:

Synonyms:1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol

Suppliers and Price of 1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol

Chemical Property:

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Technology Process of 1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol

There total 4 articles about 1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 403857-06-7
3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol

: 403857-07-8
1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/S0960-894X(02)00750-3

Reference yield:

: 924-50-5
Methyl 3,3-dimethylacrylate

: 403857-07-8
1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / CH₃SO₃H / 70 °C

2: 70 percent / LiAlH₄ / tetrahydrofuran

3: 78 percent / Et₃N / CH₂Cl₂

With lithium aluminium tetrahydride; methanesulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(02)00750-3

Reference yield:

: 500-99-2
3,5-dimethoxyphenol

: 403857-07-8
1-O-t-butyldimethylsilyl-3-(2'-hydroxy-4',6'-dimethoxyphenyl)-3,3-dimethylpropanol

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / CH₃SO₃H / 70 °C

2: 70 percent / LiAlH₄ / tetrahydrofuran

3: 78 percent / Et₃N / CH₂Cl₂

With lithium aluminium tetrahydride; methanesulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(02)00750-3