naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide

Base Information

Chemical Name:naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide
CAS No.:669009-73-8
Molecular Formula:C₂₉H₂₃IN₄O₃S
Molecular Weight:634.497
Hs Code.:

naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3<i>H</i>-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide

Synonyms:naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide

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Chemical Property of naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide

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Technology Process of naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide

There total 7 articles about naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-46-1
1-Naphthalenesulfonyl chloride

: 450841-56-2
4-[(2-amino-4-iodobenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitrile

: 669009-73-8
naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm030434f

Reference yield:

: 41252-97-5
4-iodo-2-nitrotoluene

: 669009-73-8
naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: NBS; benzoyl peroxide / CCl₄ / 48 h / Heating

2: Ag₂O / CH₂Cl₂ / 12 h / 20 °C

3: SnCl₂*2H₂O; aq. HCl / ethanol / 20 °C

4: pyridine / CH₂Cl₂ / 20 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; tin(ll) chloride; silver(l) oxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane;
DOI:10.1021/jm030434f

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 669009-73-8
naphthalene-1-sulfonic acid {2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-iodo-phenyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: t-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: tetrahydrofuran; hexane / 3 h / -78 °C

2.1: 2.52 g / aq. HCl / tetrahydrofuran; hexane; methanol

3.1: Ag₂O / CH₂Cl₂ / 12 h / 20 °C

4.1: SnCl₂*2H₂O; aq. HCl / ethanol / 20 °C

5.1: pyridine / CH₂Cl₂ / 20 °C

With pyridine; hydrogenchloride; tert.-butyl lithium; tin(ll) chloride; silver(l) oxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;
DOI:10.1021/jm030434f