2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester

Base Information

Chemical Name:2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester
CAS No.:140676-84-2
Molecular Formula:C₁₆H₁₅N₅O₆
Molecular Weight:373.325
Hs Code.:

Synonyms:2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester

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Chemical Property of 2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester

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Technology Process of 2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester

There total 3 articles about 2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72955-39-6
methyl 2-cyano-3-(2-methoxyphenyl)acrylate

: 140676-84-2
2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62.3 percent / NaBH₄, 1N NaOH / methanol; H₂O / 17 h / Ambient temperature

2: 1.) t-BuOK / 1.) DMSO, RT, 40 min, 2.) DMSO, a) RT 80 min, b) 65 deg C, 19 h

With sodium hydroxide; sodium tetrahydroborate; potassium tert-butylate; In methanol; water;
DOI:10.1021/jm00087a015

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 140676-84-2
2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73.4 percent / piperidine / dioxane / 1.) 0 deg C, 2 h, 2.) RT, 18 h

2: 62.3 percent / NaBH₄, 1N NaOH / methanol; H₂O / 17 h / Ambient temperature

3: 1.) t-BuOK / 1.) DMSO, RT, 40 min, 2.) DMSO, a) RT 80 min, b) 65 deg C, 19 h

With piperidine; sodium hydroxide; sodium tetrahydroborate; potassium tert-butylate; In 1,4-dioxane; methanol; water;
DOI:10.1021/jm00087a015

Reference yield:

: 75140-49-7
methyl 2-cyano-3-(2-methoxyphenyl)propionate

: 1007-99-4
2-amino-6-chloro-5-nitro-3H-pyrimidine-4-one

: 140676-84-2
2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester

Guidance literature:: With potassium tert-butylate; Yield given. Multistep reaction; 1.) DMSO, RT, 40 min, 2.) DMSO, a) RT 80 min, b) 65 deg C, 19 h;
DOI:10.1021/jm00087a015