Technology Process of (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid ethyl ester
There total 8 articles about (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethoxyphosphoryl-acetic acid ethyl ester;
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1.5h;
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 6.5 h / 50 - 64 °C / 6750.68 Torr
3.1: acetic acid / 0.67 h / 20 °C
3.2: 1 h / 20 °C
4.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 5 h / 20 °C
5.1: ammonium acetate / acetic acid / 1 h / 140 °C
6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2.5 h / 0 - 20 °C
7.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 - 20 °C
7.2: 2.5 h / 0 - 20 °C
With
ammonium acetate; hydrogen; sodium hydride; potassium carbonate; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 6.5 h / 50 - 64 °C / 6750.68 Torr
2.1: acetic acid / 0.67 h / 20 °C
2.2: 1 h / 20 °C
3.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 5 h / 20 °C
4.1: ammonium acetate / acetic acid / 1 h / 140 °C
5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2.5 h / 0 - 20 °C
6.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 - 20 °C
6.2: 2.5 h / 0 - 20 °C
With
ammonium acetate; hydrogen; sodium hydride; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; toluene;
