Technology Process of 4-(3,5-dimethoxyphenyl)-1-bromobutane
There total 6 articles about 4-(3,5-dimethoxyphenyl)-1-bromobutane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(3,5-dimethoxyphenyl)-1-butanol;
With
carbon tetrabromide; triphenylphosphine;
In
acetonitrile;
at 20 ℃;
for 1h;
Cooling with ice;
With
triethylamine;
In
methanol; acetonitrile;
DOI:10.1002/jlcr.1840
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / diethyl ether / 30 h / Ambient temperature
2: 1.) borane-dimethyl sulfide complex; 2.) 3N NaOH, 30percent aqueous hydrogen peroxide / 1.) dichloromethane, 0 deg C, 25 min, then r.t., 3 h; 2.) dichloromethane, ethanol, reflux, 1 h
3: 70 percent / trimethylsilyl chloride, lithium bromide / acetonitrile / 12 h / Heating
With
sodium hydroxide; chloro-trimethyl-silane; dimethylsulfide borane complex; dihydrogen peroxide; lithium bromide;
In
diethyl ether; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) borane-dimethyl sulfide complex; 2.) 3N NaOH, 30percent aqueous hydrogen peroxide / 1.) dichloromethane, 0 deg C, 25 min, then r.t., 3 h; 2.) dichloromethane, ethanol, reflux, 1 h
2: 70 percent / trimethylsilyl chloride, lithium bromide / acetonitrile / 12 h / Heating
With
sodium hydroxide; chloro-trimethyl-silane; dimethylsulfide borane complex; dihydrogen peroxide; lithium bromide;
In
acetonitrile;
