107153-18-4

Upstream product

• 1132-21-4 3,5-dimethoxybenzoic acid 
• 877-88-3 3,5-dimethoxybenzyl bromide 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 705-76-0 3,5-dimethoxybenzyl alcohol 
• 75-21-8 oxirane 
• 111540-02-4 1-(but-3-en-1-yl)-3,5-dimethoxybenzene 

Downstream Products

• 111540-03-5 4-(3,5-dimethoxyphenyl)-1-bromobutane 
• 591247-24-4 4-(3',5'-dimethoxyphenyl)butyraldehyde 
• 58545-61-2 1,3-dihydroxy-5-[5'-(2H₃)-pentyl]benzene 
• 58738-65-1 1,3-dimethoxy-5-[5'-(2H₃)-pentyl]benzene 
• 1260669-57-5 4-(3,5-dihydroxyphenyl)-1-bromobutane 
• 1305300-52-0 5-(4-bromobutyl)-4-[(1S,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol 
• 1260669-38-2 5-(4-bromobutyl)-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol 
• 1260669-54-2 5-(4-bromobutyl)-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol 
• 1305300-48-4 5-(4-bromobutyl)-3,5-bis(tert-butyldimethylsilyloxy)-2-(6-isopropenyl-3-methyl-2-cyclohexenyl)benzene 
• 1305300-50-8 1,5-bis(tert-butyldimethylsilyloxy)-2-(6-isopropenyl-3-methyl-2-cyclohexenyl)-3-pentylbenzene 
• 1305300-57-5 C₃₃H₅₅⁽³⁾H₃O₂Si₂ 
• 1305300-58-6 [pentane-5,5,5-⁽³⁾H₃]-2-(6-isopropenyl-3-methyl-2-cyclohexenyl)-3-pentylresorcinol 
• 22972-55-0 abnormal cannabidiol 
• 155733-13-4 (E,Z)-5-(3,5-dimethoxyphenyl)-1-(methylthio)-1-pentene 

Relevant academic research and scientific papers

GLYCOSIDE COMPOUND AND PREPARATION METHOD THEREFOR, COMPOSITION, APPLICATION, AND INTERMEDIATE

The present invention discloses a glycoside compound represented by Formula III, and a preparation method, a composition, use and an intermediate thereof. The glycoside compound provided in the present invention has simple preparation method, can significantly increase the expression of VEGF-A mRNA, and is effective in promoting the angiogenesis. This provides a reliable guarantee for the development of drugs with pro-angiogenic activity for treating cerebral infarction cerebral stroke, myocardial infarction, and ischemic microcirculatory disturbance of lower limbs.

Acid-catalyzed chirality-transferring intramolecular Friedel-Crafts cyclization of α-hydroxy-α-alkenylsilanes

Acid-catalyzed intramolecular Friedel-Crafts cyclization of optically active α-hydroxy-α-alkenylsilanes possessing a benzene ring (>99% ee) with TMSOTf as a Lewis acid gave enantio-enriched tetrahydronaphthalenes (up to 98% ee). The silyl group attached to the chiral carbon played a crucial role in the chirality transfer.

The preparation of [pentane-5,5,5-3H3]-abnormal- cannabidiol

A bromoalkane precursor was synthesized in six steps, and its copper catalysed coupling with methylmagnesium chloride to provide unlabelled abnormal-cannabidiol (1a) was optimized. The methodology was used for an analogous coupling using [3Hsu

Intramolecular anodic olefin coupling reactions and the use of electron-rich aryl rings

The utility of intramolecular anodic olefin coupling reactions involving electron-rich aromatic rings for constructing fused, bicyclic ring skeletons has been examined. Reactions involving alkoxy-substituted phenyl rings were found to benefit strongly from a 3-methoxy substituent on the phenyl ring. Although overoxidation of the bicyclic product was observed in these reactions, this problem could be minimized with the use of controlled potential electrolysis conditions when a monomethoxy phenyl ring was used and avoided entirely with the use of a vinyl sulfide moiety as the initiator when a more electron-rich phenyl ring was used. Reactions involving 4-alkoxy-substituted phenyl rings as substrates did not lead to good yields of fused products. Furan rings were found to be excellent coupling partners for the reactions and afforded products having fused, bicyclic furan ring skeletons. Cyclizations involving furans were shown to be compatible with the formation of both six- and seven-membered rings, the generation of a quaternary carbon, and the use of a variety of electron-rich olefins as the other coupling partner. It appears that the furan can serve as either the initiating group or the terminating group for the cyclizations. Finally, the reactions were shown to be compatible with the use of a pyrrole ring as one of the participants.

A simple and efficient synthesis of 5'-(2H3)olivetol

The title compound 1 was prepared in 13percent overall yield starting from the commercially available and inexpensive 3,5-dimethoxybenzoic acid (4).The n-pentyl side chain was elaborated from cross-coupling reactions between halides.