N-dichlorothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester

Base Information

• Chemical Name: N-dichlorothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester
• CAS No.: 76308-20-8
• Molecular Formula: C₁₀H₁₈Cl₂NO₂PS
• Molecular Weight: 318.204
• Mol file: 76308-20-8.mol

Synonyms:N-dichlorothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester

Chemical Property of N-dichlorothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-dichlorothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester

There total 5 articles about N-dichlorothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

cis-4-aminocyclohexylacetic acid ethyl ester (76308-15-1) → N-dichlorothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester (76308-20-8)

Guidance literature:

With triethylamine; trichlorophosphate; In diethyl ether;

DOI:10.1007/BF00951237

Reference yield:

4-nitrobenzeneacetic acid (104-03-0) → N-dichlorothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester (76308-20-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaOH, H₂, 2.) HCl (conc.) / 1.) Raney Ni / 1.) H₂O, 130 deg C, 150 atm, 8 h

2: 11.4 g / pyridine / 5 h / Heating

3: 86 percent / HCl (gas) / 2 h / Heating

4: 80 percent / PSCl₃, Et₃N / diethyl ether

With pyridine; hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; trichlorophosphate; nickel; In diethyl ether;

DOI:10.1007/BF00951237

Reference yield:

(cis-4-amino-cyclohexyl)-acetic acid (2952-01-4) → N-dichlorothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester (76308-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 11.4 g / pyridine / 5 h / Heating

2: 86 percent / HCl (gas) / 2 h / Heating

3: 80 percent / PSCl₃, Et₃N / diethyl ether

With pyridine; hydrogenchloride; triethylamine; trichlorophosphate; In diethyl ether;

DOI:10.1007/BF00951237

upstream raw materials:

cis-4-aminocyclohexylacetic acid ethyl ester

4-nitrobenzeneacetic acid

(cis-4-amino-cyclohexyl)-acetic acid

cis-4-aminocyclohexylacetic acid hydrochloride

Downstream raw materials:

N-diethyleneimidothiophosphoryl-cis-4-aminocyclohexylacetic acid ethyl ester

C₁₂H₂₁N₃O₂PS^(1-)*Na⁽¹⁺⁾