2-(4-Fluoro-2-iodophenyl)acetonitrile

Base Information

Chemical Name:2-(4-Fluoro-2-iodophenyl)acetonitrile
CAS No.:70931-60-1
Molecular Formula:C₈H₅FIN
Molecular Weight:261.037
Hs Code.:
European Community (EC) Number:898-268-4
DSSTox Substance ID:DTXSID901297621
Wikidata:Q107962999

Synonyms:70931-60-1;2-(4-fluoro-2-iodophenyl)acetonitrile;SCHEMBL11351476;4-Fluoro-2-iodobenzeneacetonitrile;DTXSID901297621;AKOS005215804;EN300-6776535

Suppliers and Price of 2-(4-Fluoro-2-iodophenyl)acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Fluoro-2-iodophenyl)acetonitrile

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:260.94507
Heavy Atom Count:11
Complexity:174

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)I)CC#N

Technology Process of 2-(4-Fluoro-2-iodophenyl)acetonitrile

There total 4 articles about 2-(4-Fluoro-2-iodophenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 446-10-6
2-nitro-4-fluorotoluene

: 70931-60-1
(4-fluoro-2-iodophenyl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: N₂H₄*H₂O, FeCl₃ / ethanol / Heating

2: (i) NaNO₂, aq. HCl, (ii) aq. KI, H₂SO₄

3: NBS, (PhCO)2O₂ / CCl₄ / Heating; Irradiation

4: dimethylformamide / 105 - 110 °C

With N-Bromosuccinimide; iron(III) chloride; hydrazine hydrate; dibenzoyl peroxide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1135/cccc19792108

Reference yield:

: 13194-67-7
4-fluoro-2-iodotoluene

: 70931-60-1
(4-fluoro-2-iodophenyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: NBS, (PhCO)2O₂ / CCl₄ / Heating; Irradiation

2: dimethylformamide / 105 - 110 °C

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1135/cccc19792108

Reference yield:

: 367-29-3
3-fluoro-6-methylaniline

: 70931-60-1
(4-fluoro-2-iodophenyl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: (i) NaNO₂, aq. HCl, (ii) aq. KI, H₂SO₄

2: NBS, (PhCO)2O₂ / CCl₄ / Heating; Irradiation

3: dimethylformamide / 105 - 110 °C

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1135/cccc19792108