2-(4-diethylaminophenyl)-8-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Base Information

Chemical Name:2-(4-diethylaminophenyl)-8-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline
CAS No.:1374107-22-8
Molecular Formula:C₃₄H₄₀N₂O₆S
Molecular Weight:604.767
Hs Code.:

Synonyms:2-(4-diethylaminophenyl)-8-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

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Chemical Property of 2-(4-diethylaminophenyl)-8-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

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Technology Process of 2-(4-diethylaminophenyl)-8-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

There total 6 articles about 2-(4-diethylaminophenyl)-8-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 1374108-58-3
C₂₉H₃₂N₂O₅S

: 1374107-22-8
2-(4-diethylaminophenyl)-8-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 42h;

Reference yield:

: 15450-76-7
quinoline-2,8-diol

: 1374107-22-8
2-(4-diethylaminophenyl)-8-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride; N,N-dimethyl-formamide / 5.5 h / 20 - 50 °C / Cooling with ice

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

4: hydrogenchloride / methanol; water / 1 h / 70 °C

5: pyridine / tetrahydrofuran / 0.5 h / Cooling with ice

6: toluene-4-sulfonic acid / tetrahydrofuran / 42 h / 20 °C

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; di-isopropyl azodicarboxylate; potassium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water;

Reference yield:

: 1374108-55-0
C₁₅H₁₆ClNO₃

: 1374107-22-8
2-(4-diethylaminophenyl)-8-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

2: hydrogenchloride / methanol; water / 1 h / 70 °C

3: pyridine / tetrahydrofuran / 0.5 h / Cooling with ice

4: toluene-4-sulfonic acid / tetrahydrofuran / 42 h / 20 °C

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water;