1H-Pyrrole-3-carboxylicacid,4-amino-2,5-dihydro-5-(hydroxymethyl)-2-oxo-,ethylester,(5S)-

Base Information

Chemical Name:1H-Pyrrole-3-carboxylicacid,4-amino-2,5-dihydro-5-(hydroxymethyl)-2-oxo-,ethylester,(5S)-
CAS No.:195525-52-1
Molecular Formula:C₈H₁₂N₂O₄
Molecular Weight:200.194
Hs Code.:
Mol file:195525-52-1.mol

Synonyms:1H-Pyrrole-3-carboxylicacid, 4-amino-2,5-dihydro-5-(hydroxymethyl)-2-oxo-, ethyl ester, (S)-

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Chemical Property of 1H-Pyrrole-3-carboxylicacid,4-amino-2,5-dihydro-5-(hydroxymethyl)-2-oxo-,ethylester,(5S)-

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

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Technology Process of 1H-Pyrrole-3-carboxylicacid,4-amino-2,5-dihydro-5-(hydroxymethyl)-2-oxo-,ethylester,(5S)-

There total 3 articles about 1H-Pyrrole-3-carboxylicacid,4-amino-2,5-dihydro-5-(hydroxymethyl)-2-oxo-,ethylester,(5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 195525-49-6
(+)-(1R,3aS,3bR,6aR)-7-oxo-1-phenyl-2,3,3a,3b,6,6a,7,7a-octahydro-1H-2-oxa-4,5,6,7a-tetraazacyclopenta[a]pentalene-6a-carboxylic acid ethyl ester

: 195525-52-1
4-amino-5-hydroxymethyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1039/b106782f

Reference yield: 40.0%

: 195525-50-9
(+)-(1R,3aS,3bR,6aR)-6-acetyl-7-oxo-1-phenyl-2,3,3a,3b,6,6a,7,7a-octahydro-1H-2-oxa-4,5,6,7a-tetraazacyclopenta[a]pentalene-6a-carboxylic acid ethyl ester

: 195525-52-1
4-amino-5-hydroxymethyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(97)01312-9

Reference yield:

: 166765-36-2
(2R,5S)-7-ethoxycarbonyl-8-oxo-2-phenyl-1-aza-3-oxa-bicyclo[3.3.0]oct-6-ene

: 195525-52-1
4-amino-5-hydroxymethyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NaN₃; aq. acetic acid / tetrahydrofuran / 0.5 h / 20 °C

2: 40 percent / TFA / CH₂Cl₂ / 0.25 h / 20 °C

With sodium azide; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b106782f