3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester

Base Information

• Chemical Name: 3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester
• CAS No.: 335255-91-9
• Molecular Formula: C₁₇H₂₀N₂O₃
• Molecular Weight: 300.357

Synonyms:3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester

Chemical Property of 3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester

Chemical Property:

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Technology Process of 3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester

There total 1 articles about 3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-aminobenzoic acid ethyl ester (582-33-2) + ethyl 3-(2-methyl-imidazol-1-yl)-benzoate (335255-92-0) + lithium tert.-butyl acetate (66519-62-8) + ethyl acetimidate hydrochloride (2208-07-3) + 2,2-diethoxy-ethanamine (645-36-3) → 3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester (335255-91-9)

Guidance literature:

With sulfuric acid; In ethanol;

Reference yield:

3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester (335255-91-9) + (5-amino-2'-fluoro-2-methoxy-biphenyl-4-yl)-carbamic acid tert.-butyl ester (335351-19-4) → (2'-fluoro-2-methoxy-5-{3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert.-butyl ester (335351-83-2)

Guidance literature:

Reference yield:

3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester (335255-91-9) + (5-amino-2-tert.-butoxy-4'-fluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (335351-16-1) → (2-tert.-butoxy-4'-fluoro-5-{3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert.-butyl ester (335351-87-6)

Guidance literature:

upstream raw materials:

3-aminobenzoic acid ethyl ester

ethyl 3-(2-methyl-imidazol-1-yl)-benzoate

lithium tert.-butyl acetate

ethyl acetimidate hydrochloride

Downstream raw materials:

(2-tert.-butoxy-4'-fluoro-5-{3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert.-butyl ester

(2'-fluoro-2-methoxy-5-{3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert.-butyl ester

(4'-fluoro-3-{3-[3-(2-methyl-imidazol-1-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert.-butyl ester

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