(3-(3-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)-propyl)phosphonic acid

Base Information

Chemical Name:(3-(3-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)-propyl)phosphonic acid
CAS No.:1447961-05-8
Molecular Formula:C₁₉H₁₉Cl₂N₄O₅P
Molecular Weight:485.263
Hs Code.:

Synonyms:(3-(3-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)-propyl)phosphonic acid

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Chemical Property of (3-(3-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)-propyl)phosphonic acid

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Technology Process of (3-(3-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)-propyl)phosphonic acid

There total 7 articles about (3-(3-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)-propyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1447961-27-4
C₂₃H₂₇Cl₂N₄O₅P

: 1447961-05-8
(3-(3-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)-propyl)phosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm4006498

Reference yield:

: 151169-75-4
3,4-dichlophenylboronic acid

: 1447961-05-8
(3-(3-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)-propyl)phosphonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium diacetate; p-benzoquinone; 2.9-dimethyl-1,10-phenanthroline / 100 °C / Microwave irradiation

2.1: phenol / 100 °C

2.2: 100 °C

3.1: pyridine / ethanol / 20 °C

3.2: 20 °C

4.1: triethylamine; C₅H₉O₆P / ethyl acetate / 3 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 760.05 Torr

6.1: trimethylsilyl bromide / dichloromethane / 20 h / 20 °C / Inert atmosphere

With pyridine; 2.9-dimethyl-1,10-phenanthroline; trimethylsilyl bromide; palladium 10% on activated carbon; C₅H₉O₆P; hydrogen; palladium diacetate; triethylamine; p-benzoquinone; phenol; In methanol; ethanol; dichloromethane; ethyl acetate; 1.1: |Heck Reaction;
DOI:10.1021/jm4006498

Reference yield:

: 857284-23-2
3-[(1H-1,2,4-triazol-1-yl)methyl]benzoic acid

: 1447961-05-8
(3-(3-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)-propyl)phosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; C₅H₉O₆P / ethyl acetate / 3 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 760.05 Torr

3: trimethylsilyl bromide / dichloromethane / 20 h / 20 °C / Inert atmosphere

With trimethylsilyl bromide; palladium 10% on activated carbon; C₅H₉O₆P; hydrogen; triethylamine; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm4006498