4-N,N'-dimethylamino-4'-(1,3-dihydroxypropane-2-ylmethoxy)stilbene

Base Information

• Chemical Name: 4-N,N'-dimethylamino-4'-(1,3-dihydroxypropane-2-ylmethoxy)stilbene
• CAS No.: 902143-05-9
• Molecular Formula: C₂₀H₂₅NO₃
• Molecular Weight: 327.423
• Mol file: 902143-05-9.mol

Synonyms:4-N,N'-dimethylamino-4'-(1,3-dihydroxypropane-2-ylmethoxy)stilbene

Chemical Property of 4-N,N'-dimethylamino-4'-(1,3-dihydroxypropane-2-ylmethoxy)stilbene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-N,N'-dimethylamino-4'-(1,3-dihydroxypropane-2-ylmethoxy)stilbene

There total 1 articles about 4-N,N'-dimethylamino-4'-(1,3-dihydroxypropane-2-ylmethoxy)stilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-N,N'-dimethylamino-4'-(2,2-dimethyl-[l,3]dioxane-5-ylmethoxy)stilbene (902143-04-8) → 4-N,N'-dimethylamino-4'-(1,3-dihydroxypropane-2-ylmethoxy)stilbene (902143-05-9)

Guidance literature:

With hydrogenchloride; In acetone; at 0 - 20 ℃;

DOI:10.1021/jm050166g

Reference yield: 41.0%

4-N,N'-dimethylamino-4'-(1,3-dihydroxypropane-2-ylmethoxy)stilbene (902143-05-9) + p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 3-{4-[2-(4-(dimethylamino)phenyl)vinyl]phenoxy}-2-hydroxymethylpropyl ester (902143-06-0)

Guidance literature:

With pyridine; at 0 ℃; for 2h;

DOI:10.1021/jm050166g

Reference yield:

4-N,N'-dimethylamino-4'-(1,3-dihydroxypropane-2-ylmethoxy)stilbene (902143-05-9) → 4-N,N'-dimethylamino-4'-(1-fluoro-3-hydroxypropane-2-ylmethoxy)stilbene

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / pyridine / 2 h / 0 °C

2: 62 percent / TBAF / tetrahydrofuran / 3 h / Heating

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/jm050166g

upstream raw materials:

4-N,N'-dimethylamino-4'-(2,2-dimethyl-[l,3]dioxane-5-ylmethoxy)stilbene

Downstream raw materials:

toluene-4-sulfonic acid 3-{4-[2-(4-(dimethylamino)phenyl)vinyl]phenoxy}-2-hydroxymethylpropyl ester