N-(4-(4-(3,5-bis(trifluoromethyl)benzylamino)phenethyl)phenyl)-3,5-dimethylbenzamide

Base Information

Chemical Name:N-(4-(4-(3,5-bis(trifluoromethyl)benzylamino)phenethyl)phenyl)-3,5-dimethylbenzamide
CAS No.:1263380-25-1
Molecular Formula:C₃₂H₂₈F₆N₂O
Molecular Weight:570.578
Hs Code.:

Synonyms:N-(4-(4-(3,5-bis(trifluoromethyl)benzylamino)phenethyl)phenyl)-3,5-dimethylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(4-(3,5-bis(trifluoromethyl)benzylamino)phenethyl)phenyl)-3,5-dimethylbenzamide

Chemical Property:

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Technology Process of N-(4-(4-(3,5-bis(trifluoromethyl)benzylamino)phenethyl)phenyl)-3,5-dimethylbenzamide

There total 7 articles about N-(4-(4-(3,5-bis(trifluoromethyl)benzylamino)phenethyl)phenyl)-3,5-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₂₆F₆N₂O

: 1263380-25-1
N-(4-(4-(3,5-bis(trifluoromethyl)benzylamino)phenethyl)phenyl)-3,5-dimethylbenzamide

Guidance literature:: With sodium tetrahydroborate; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol1027915

Reference yield:

: 954407-13-7
C₂₇H₂₉N₃O₅

: 401-95-6
3,5-Bis(trifluoromethyl)benzaldehyde

: 1263380-23-9
N-(4-(4-azidophenethyl)phenyl)-3,5-dimethylbenzamide

: 1263380-25-1
N-(4-(4-(3,5-bis(trifluoromethyl)benzylamino)phenethyl)phenyl)-3,5-dimethylbenzamide

: 1263380-26-2
C₂₇H₂₉N₃O₅*C₃₂H₂₈F₆N₂O

Guidance literature:: C₂₇H₂₉N₃O₅; N-(4-(4-azidophenethyl)phenyl)-3,5-dimethylbenzamide; In chloroform-d1; at -10 ℃; for 1h;

With triphenylphosphine; In chloroform-d1; for 48h; Inert atmosphere;

3,5-Bis(trifluoromethyl)benzaldehyde; Further stages;
DOI:10.1021/ol1027915

Reference yield:

: 621-95-4
4,4'-diaminodihydrostilbene

: 1263380-25-1
N-(4-(4-(3,5-bis(trifluoromethyl)benzylamino)phenethyl)phenyl)-3,5-dimethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 19 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / -10 °C

2.2: -10 - 20 °C

3.1: chloroform-d1 / 1 h / -10 °C

3.2: 48 h / Inert atmosphere

3.3: 24 h / 20 °C

4.1: sodium tetrahydroborate / acetonitrile / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; triethylamine; sodium nitrite; In chloroform-d1; dichloromethane; water; acetonitrile; 3.2: aza-Wittig reaction / 3.3: aza-Wittig reaction;
DOI:10.1021/ol1027915