methyl (3R,5S)-5-phenyl-4-benzyl-3-<4-(tert-butyldimethylsiloxy)phenyl>-4-azahexanoate

Base Information

Chemical Name:methyl (3R,5S)-5-phenyl-4-benzyl-3-<4-(tert-butyldimethylsiloxy)phenyl>-4-azahexanoate
CAS No.:161925-56-0
Molecular Formula:C₃₁H₄₁NO₃Si
Molecular Weight:503.757
Hs Code.:

Synonyms:methyl (3R,5S)-5-phenyl-4-benzyl-3-<4-(tert-butyldimethylsiloxy)phenyl>-4-azahexanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (3R,5S)-5-phenyl-4-benzyl-3-<4-(tert-butyldimethylsiloxy)phenyl>-4-azahexanoate

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Technology Process of methyl (3R,5S)-5-phenyl-4-benzyl-3-<4-(tert-butyldimethylsiloxy)phenyl>-4-azahexanoate

There total 3 articles about methyl (3R,5S)-5-phenyl-4-benzyl-3-<4-(tert-butyldimethylsiloxy)phenyl>-4-azahexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3943-97-3
methyl 4-hydroxycinnamate

: 161925-56-0
methyl (3R,5S)-5-phenyl-4-benzyl-3-<4-(tert-butyldimethylsiloxy)phenyl>-4-azahexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / imidazole / dimethylformamide / 1 h / 0 °C

2: 1.) BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, -78 deg C, 20 min

With 1H-imidazole; n-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1055/s-1995-3870

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 161925-56-0
methyl (3R,5S)-5-phenyl-4-benzyl-3-<4-(tert-butyldimethylsiloxy)phenyl>-4-azahexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / imidazole / dimethylformamide / 1 h / 0 °C

2: 1.) BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, -78 deg C, 20 min

With 1H-imidazole; n-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1055/s-1995-3870

Reference yield:

: 17480-69-2
(S)-N-benzyl-1-phenylethylamine

: 426207-35-4
(E)-methyl 3-(4-(tert-butyldimethylsilyloxy)phenyl)acrylate

: 161925-56-0
methyl (3R,5S)-5-phenyl-4-benzyl-3-<4-(tert-butyldimethylsiloxy)phenyl>-4-azahexanoate

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, -78 deg C, 20 min;
DOI:10.1055/s-1995-3870