(4-(Piperidin-1-ylsulfonyl)phenyl)methanamine

Base Information

• Chemical Name: (4-(Piperidin-1-ylsulfonyl)phenyl)methanamine
• CAS No.: 205259-71-8
• Molecular Formula: C₁₂H₁₈N₂O₂S
• Molecular Weight: 254.353
• DSSTox Substance ID: DTXSID80407038
• Wikidata: Q82212253
• Mol file: 205259-71-8.mol

Synonyms:205259-71-8;(4-(Piperidin-1-ylsulfonyl)phenyl)methanamine;1-[4-(piperidin-1-ylsulfonyl)phenyl]methanamine;(4-piperidin-1-ylsulfonylphenyl)methanamine;[4-(piperidine-1-sulfonyl)phenyl]methanamine;SCHEMBL5018821;DTXSID80407038;BCDIURNDMMBMJT-UHFFFAOYSA-N;MFCD06090860;AKOS000200356;4-(Piperidine-1-sulfonyl)-benzylamine;SB43905;BS-14094;FT-0717379;EN300-13106;Benzenemethanamine, 4-(1-piperidinylsulfonyl)-;A879582

Chemical Property of (4-(Piperidin-1-ylsulfonyl)phenyl)methanamine

Chemical Property:

• Storage Temp.: 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 254.10889899
• Heavy Atom Count: 17
• Complexity: 323

Purity/Quality:

97% ^*data from raw suppliers

(4-(Piperidin-1-ylsulfonyl)phenyl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)CN

Technology Process of (4-(Piperidin-1-ylsulfonyl)phenyl)methanamine

There total 6 articles about (4-(Piperidin-1-ylsulfonyl)phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

4-(piperidine-1-sulfonyl)-benzonitrile (227935-30-0) → (4-(piperidin-1-ylsulfonyl)phenyl)methanamine (205259-71-8)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; water; at 20 ℃; under 760.051 Torr;

Reference yield:

C17H26N2O4S → (4-(piperidin-1-ylsulfonyl)phenyl)methanamine (205259-71-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h;

Reference yield:

p-cyanobenzenesulfonyl chloride (49584-26-1) → (4-(piperidin-1-ylsulfonyl)phenyl)methanamine (205259-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: hydrogen; ammonium hydroxide / water; methanol / 20 °C / 760.05 Torr

With ammonium hydroxide; hydrogen; triethylamine; In methanol; dichloromethane; water;

upstream raw materials:

p-cyanobenzenesulfonyl chloride

piperidine

4-(piperidine-1-sulfonyl)-benzonitrile

C₁₅H₁₅NO₃S

Downstream raw materials:

N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}thieno[3,2-c]pyridine-2-carboxamide

imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide

pyrazolo[1,5-a]pyridine-5-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide

1H-pyrazolo[4,3-b]pyridine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide