imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide

Base Information

Chemical Name:imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide
CAS No.:1453173-76-6
Molecular Formula:C₁₉H₂₁N₅O₃S
Molecular Weight:399.473
Hs Code.:

Synonyms:imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide

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Chemical Property of imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide

Chemical Property:

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Technology Process of imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide

There total 6 articles about imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 205259-71-8
(4-(piperidin-1-ylsulfonyl)phenyl)methanamine

: 769109-13-9
imidazo[1,2-b]pyridazine-6-carboxylic acid

: 1453173-76-6
imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 1234616-21-7
imidazo[1,2-b]pyridazine-6-carboxylic acid methyl ester

: 1453173-76-6
imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / tetrahydrofuran / 20 °C

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 6775-78-6
6-chloroimidazo[1,2-b]pyridazine

: 1453173-76-6
imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / 110 °C / 7600.51 Torr

2: water; sodium hydroxide / tetrahydrofuran / 20 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;