N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester

Base Information

Chemical Name:N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester
CAS No.:169320-28-9
Molecular Formula:C₂₂H₃₂N₂O₆
Molecular Weight:420.506
Hs Code.:

Synonyms:N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester

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Chemical Property of N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester

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Technology Process of N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester

There total 4 articles about N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 35264-09-6
1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

: 4089-07-0
L-tyrosine ethyl ester monohydrochloride

: 169320-28-9
N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester

Guidance literature:: 1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -10 ℃; for 0.5h; Inert atmosphere;

L-tyrosine ethyl ester monohydrochloride; With triethylamine; at -5 ℃; for 2h; Inert atmosphere;
DOI:10.1021/op970242s

Reference yield: 62.0%

: 949-67-7
L-tyrosine ethyl ester

: 35264-09-6
1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

: 169320-28-9
N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm960323z

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 169320-28-9
N-[[1-[[(1,1-dimethylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 18 h / 55 °C / Inert atmosphere

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

2.2: 2 h / -5 °C / Inert atmosphere

With triethylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1021/op970242s