ACPT-II

Base Information

• Chemical Name: ACPT-II
• CAS No.: 195209-04-2
• Molecular Formula: C₈H₁₁NO₆
• Molecular Weight: 217.178
• Mol file: 195209-04-2.mol

Synonyms:ACPT-I;ACPT-II

Chemical Property of ACPT-II

Chemical Property:

• PSA: 137.92000
• LogP: -0.33580
• Storage Temp.: Desiccate at -20°C

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

ACPT-II ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: ACPT-II is a metabotropic glutamate receptor agonist, which exerts neuroprotective effects against kainate-induced excitotoxicity in primary neuronal cell and the dorsal hippocampus of rats.

Technology Process of ACPT-II

There total 9 articles about ACPT-II which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Dioxo-1,3-diaza-spiro[4.4]nonane-3,7,8-tricarboxylic acid 3-tert-butyl ester → (+)-(3S,4S)-ACPT-III + ACPT-II (195209-04-2) + ACPT-I (194918-76-8)

Guidance literature:

With lithium hydroxide; In acetonitrile; for 5h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jm970207b

Reference yield:

2,4-Dioxo-1,3-diaza-spiro[4.4]nonane-3,7,8-tricarboxylic acid 3-tert-butyl ester → (-)-(3R,4R)-ACPT-III + ACPT-II (195209-04-2) + ACPT-I (194918-76-8)

Guidance literature:

With lithium hydroxide; In acetonitrile; for 5h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jm970207b

Reference yield:

2,4-Dioxo-1,3-diaza-spiro[4.4]nonane-3,7,8-tricarboxylic acid 3-tert-butyl ester → (3RS,4RS)-1-aminocyclopentane-1,3,4-tricarboxylic acid + ACPT-II (195209-04-2) + ACPT-I (194918-76-8)

Guidance literature:

With lithium hydroxide; In acetonitrile; for 5h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jm970207b

upstream raw materials:

(+)-(1S,2S)-dimethyl-4-oxocyclopentane 1,2-dicarboxylate

potassium cyanide

ammonium carbonate

(+/-)-trans-4-oxo-1,2-cyclopentanedicarboxylic acid bis(methyl ester)