(R)-methyl-3-({2-[2-(tert-butylcarbamate)-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoate

Base Information

Chemical Name:(R)-methyl-3-({2-[2-(tert-butylcarbamate)-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoate
CAS No.:868286-26-4
Molecular Formula:C₂₆H₃₄N₄O₈S
Molecular Weight:562.644
Hs Code.:

Synonyms:(R)-methyl-3-({2-[2-(tert-butylcarbamate)-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoate

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Chemical Property of (R)-methyl-3-({2-[2-(tert-butylcarbamate)-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoate

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Technology Process of (R)-methyl-3-({2-[2-(tert-butylcarbamate)-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoate

There total 7 articles about (R)-methyl-3-({2-[2-(tert-butylcarbamate)-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868286-25-3
(R)-tert-butyl (1-hydrazinyl-2-methyl-1-oxo-3-phenylpropan-2-yl)carbamate

: 695215-94-2
3-(methoxycarbonyl)-5-[methyl(methylsulfonyl)amino]benzoic acid

: 868286-26-4
(R)-methyl-3-({2-[2-(tert-butylcarbamate)-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 62814-45-3
5-methanesulphonylamino-isophthalic acid dimethyl ester

: 868286-26-4
(R)-methyl-3-({2-[2-(tert-butylcarbamate)-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h

2: methanol; sodium hydroxide / tetrahydrofuran / 8 h / 0 - 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C

With methanol; sodium hydroxide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 868286-26-4
(R)-methyl-3-({2-[2-(tert-butylcarbamate)-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 1,4-dioxane; water / 14 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine / acetonitrile / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydrazine; In 1,4-dioxane; dichloromethane; water; acetonitrile;