Technology Process of methyl N-(5-acetyl-2-methylphenoxy)carbamate
There total 5 articles about methyl N-(5-acetyl-2-methylphenoxy)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(3-hydroxy-4-methylphenyl)ethanone;
With
potassium tert-butylate;
In
methanol;
at 20 ℃;
for 1h;
With
mesitylenesulfonylhydroxylamine;
In
diethyl ether; N,N-dimethyl-formamide;
for 0.166667h;
Cooling with ice;
methyl chloroformate;
With
pyridine;
In
diethyl ether; N,N-dimethyl-formamide;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C
1.3: -78 °C
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3.1: potassium tert-butylate / methanol / 1 h / 20 °C
3.2: 0.17 h / Cooling with ice
3.3: 1 h
With
n-butyllithium; potassium tert-butylate; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / 1,5-dimethyl-2-imidazolidone / 1 h / 110 °C
2.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 °C
2.3: -78 °C
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4.1: potassium tert-butylate / methanol / 1 h / 20 °C
4.2: 0.17 h / Cooling with ice
4.3: 1 h
With
n-butyllithium; potassium tert-butylate; sodium hydride; trifluoroacetic acid;
In
tetrahydrofuran; methanol; 1,5-dimethyl-2-imidazolidone; dichloromethane;
