Technology Process of Benzoic acid (R)-4-[(3R,3aR,5aS,6R,9aS,9bS)-6-(2-carboxy-ethyl)-3a,6-dimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-3-yl]-pentyl ester
There total 9 articles about Benzoic acid (R)-4-[(3R,3aR,5aS,6R,9aS,9bS)-6-(2-carboxy-ethyl)-3a,6-dimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-3-yl]-pentyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
24-(benzoyloxy)-chol-4-en-3-one;
With
ozone; acetic acid;
In
ethyl acetate;
at -20 - -10 ℃;
With
dihydrogen peroxide; acetic acid;
In
water; ethyl acetate;
at 20 ℃;
Further stages.;
DOI:10.1021/jo0259109
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 91 percent / Jones reagent / acetone / 0.17 h / 0 °C
2.1: bromine; acetic acid / 20 °C
3.1: 68 percent / Li2CO3; LiBr / dimethylformamide / 150 °C
4.1: 10percent NaOH / ethanol / 1.5 h / 20 °C
5.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C
6.1: 72 percent / sodium borohydride / tetrahydrofuran; H2O / 0 °C
7.1: 92 percent / triethylamine / tetrahydrofuran
8.1: ozone; acetic acid / ethyl acetate / -20 - -10 °C
8.2: 30percent hydrogen peroxide; acetic acid / ethyl acetate; H2O / 20 °C
With
sodium tetrahydroborate; jones reagent; bromine; lithium carbonate; ozone; acetic acid; triethylamine; lithium bromide;
In
tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
1.1: Jones oxidation;
DOI:10.1021/jo0259109
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 10percent NaOH / ethanol / 1.5 h / 20 °C
2.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C
3.1: 72 percent / sodium borohydride / tetrahydrofuran; H2O / 0 °C
4.1: 92 percent / triethylamine / tetrahydrofuran
5.1: ozone; acetic acid / ethyl acetate / -20 - -10 °C
5.2: 30percent hydrogen peroxide; acetic acid / ethyl acetate; H2O / 20 °C
With
sodium tetrahydroborate; ozone; acetic acid; triethylamine;
In
tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1021/jo0259109
