3α-Oxochola-4-ene-24-oic acid methyl ester

Base Information

• Chemical Name: 3α-Oxochola-4-ene-24-oic acid methyl ester
• CAS No.: 1452-33-1
• Molecular Formula: C25H38O3
• Molecular Weight: 386.575
• Mol file: 1452-33-1.mol

Synonyms:3-Oxochol-4-en-24-oic acid methyl ester;3α-Oxochola-4-ene-24-oic acid methyl ester

Chemical Property of 3α-Oxochola-4-ene-24-oic acid methyl ester

Chemical Property:

• PSA: 43.37000
• LogP: 5.72380

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3α-Oxochola-4-ene-24-oic acid methyl ester

There total 31 articles about 3α-Oxochola-4-ene-24-oic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-oxo-4-cholenic acid (1452-29-5) → methyl 3-oxo-4-cholenolate (1452-33-1)

Guidance literature:

With hydrogenchloride; for 8h; Ambient temperature;

Reference yield: 68.0%

(R)-4-((5S,8S,9S,10R,13R,14S,17R)-4-Bromo-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester (112018-64-1) → methyl 3-oxo-4-cholenolate (1452-33-1)

Guidance literature:

With lithium carbonate; lithium bromide; In N,N-dimethyl-formamide; at 150 ℃;

DOI:10.1021/jo0259109

Reference yield: 64.0%

methyl 5-cholenoate (20231-57-6) → methyl 3-oxo-4-cholenolate (1452-33-1)

Guidance literature:

With aluminum isopropoxide; In 1-methyl-pyrrolidin-2-one; toluene; for 3h; Reflux;

upstream raw materials:

diazomethane

3-oxo-4-cholenic acid

2,4,6-trimethyl-pyridine

6α-(toluene-sulfonyl-(4)-oxy)-3-oxo-5β-cholanoic acid-(24)-methyl ester

Downstream raw materials:

methyl 3β-hydroxy-5α-cholan-24-oate

methyl lithocholate

24-(benzoyloxy)-4-oxachol-5-en-3-one

24-(benzoyloxy)-chol-4-en-3-one