Technology Process of 1-(3-benzyl-5-boronic acid-phenyl)-ethanone
There total 6 articles about 1-(3-benzyl-5-boronic acid-phenyl)-ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3-benzyl-5-bromo-phenyl)-2-methyl-[1,3]dioxolane;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
Cooling with acetone-dry ice;
With
Trimethyl borate;
In
tetrahydrofuran;
at -78 - 20 ℃;
With
hydrogenchloride;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / toluene / Heating / reflux
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Cooling with acetone-dry ice
2.2: -78 - 20 °C
2.3: 2 h
With
n-butyllithium; toluene-4-sulfonic acid;
In
tetrahydrofuran; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / hexanes; diethyl ether / 0.5 h / -78 °C
1.2: -78 - 0 °C
2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 20 °C
3.1: n-butyllithium / diethyl ether / 0.25 h / -78 °C / Cooling with acetone-dry ice
3.2: 1 h / -78 - 20 °C
4.1: toluene-4-sulfonic acid / toluene / Heating / reflux
5.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Cooling with acetone-dry ice
5.2: -78 - 20 °C
5.3: 2 h
With
triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid;
In
tetrahydrofuran; hexanes; diethyl ether; dichloromethane; toluene;
![2-(3-benzyl-5-bromo-phenyl)-2-methyl-[1,3]dioxolane](/Databaselist/images/loading.webp)
