1-{3-benzyl-5-[6-(2-morpholin-4-yl-ethylamino)-pyrazin-2-yl]-phenyl}-ethanone

Base Information

Chemical Name:1-{3-benzyl-5-[6-(2-morpholin-4-yl-ethylamino)-pyrazin-2-yl]-phenyl}-ethanone
CAS No.:317334-68-2
Molecular Formula:C₂₅H₂₈N₄O₂
Molecular Weight:416.523
Hs Code.:

Synonyms:1-{3-benzyl-5-[6-(2-morpholin-4-yl-ethylamino)-pyrazin-2-yl]-phenyl}-ethanone

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Chemical Property of 1-{3-benzyl-5-[6-(2-morpholin-4-yl-ethylamino)-pyrazin-2-yl]-phenyl}-ethanone

Chemical Property:

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Technology Process of 1-{3-benzyl-5-[6-(2-morpholin-4-yl-ethylamino)-pyrazin-2-yl]-phenyl}-ethanone

There total 8 articles about 1-{3-benzyl-5-[6-(2-morpholin-4-yl-ethylamino)-pyrazin-2-yl]-phenyl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 317334-67-1
1-[3-benzyl-5-(6-bromo-pyrazin-2-yl)-phenyl]-ethanone

: 317334-68-2
1-{3-benzyl-5-[6-(2-morpholin-4-yl-ethylamino)-pyrazin-2-yl]-phenyl}-ethanone

Guidance literature:: With triethylamine; In 1,4-dioxane; Heating / reflux;

Reference yield:

: 317334-65-9
2-(3-benzyl-5-bromo-phenyl)-2-methyl-[1,3]dioxolane

: 317334-68-2
1-{3-benzyl-5-[6-(2-morpholin-4-yl-ethylamino)-pyrazin-2-yl]-phenyl}-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Cooling with acetone-dry ice

1.2: -78 - 20 °C

1.3: 2 h

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 4 h / Heating / reflux

3.1: triethylamine / 1,4-dioxane / Heating / reflux

With n-butyllithium; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene;

Reference yield:

: 317334-66-0
1-(3-benzyl-5-boronic acid-phenyl)-ethanone

: 317334-68-2
1-{3-benzyl-5-[6-(2-morpholin-4-yl-ethylamino)-pyrazin-2-yl]-phenyl}-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 4 h / Heating / reflux

2: triethylamine / 1,4-dioxane / Heating / reflux

With sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; toluene;