4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(4-methylphenylsulfonyl)-2,3-dihydro-3-pyridazinone

Base Information

Chemical Name:4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(4-methylphenylsulfonyl)-2,3-dihydro-3-pyridazinone
CAS No.:1363808-47-2
Molecular Formula:C₂₄H₂₈N₂O₃S
Molecular Weight:424.564
Hs Code.:

Synonyms:4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(4-methylphenylsulfonyl)-2,3-dihydro-3-pyridazinone

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Chemical Property of 4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(4-methylphenylsulfonyl)-2,3-dihydro-3-pyridazinone

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Technology Process of 4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(4-methylphenylsulfonyl)-2,3-dihydro-3-pyridazinone

There total 13 articles about 4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(4-methylphenylsulfonyl)-2,3-dihydro-3-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363808-44-9
1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-1-methyl-2-[1-(4-methylphenylsulfonyl)-2-propylidene]hydrazine

: 1363808-47-2
4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(4-methylphenylsulfonyl)-2,3-dihydro-3-pyridazinone

Guidance literature:: 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-1-methyl-2-[1-(4-methylphenylsulfonyl)-2-propylidene]hydrazine; With methanol; lithium hydroxide monohydrate; In toluene; at 0 - 5 ℃; for 20h;

With sulfuric acid; In toluene; pH=1;

Reference yield:

: 314084-61-2
1-bromo-2,6-diethyl-4-methylbenzene

: 1363808-47-2
4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(4-methylphenylsulfonyl)-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium; ethylene dibromide / toluene; tetrahydrofuran / 52 h / 40 - 50 °C / Inert atmosphere

1.2: 2 h / 0 - 5 °C / Inert atmosphere

2.1: hydrazine hydrate / methanol / 4.08 h / 1 - 2 °C

3.1: toluene / 2 h / 50 °C / 100 Torr / Inert atmosphere

4.1: potassium carbonate / acetone / 1.5 h / 20 °C / Inert atmosphere

5.1: hydrogen / 5%-palladium/activated carbon / 1,2-dimethoxyethane / 8 h / 20 °C

6.1: toluene / 7.5 h / 45 - 60 °C / 100 - 120 Torr

7.1: methanol; lithium hydroxide monohydrate / toluene / 20 h / 0 - 5 °C

7.2: pH 1

With methanol; lithium hydroxide monohydrate; hydrogen; potassium carbonate; hydrazine hydrate; magnesium; ethylene dibromide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; acetone; toluene;

Reference yield:

: 1363806-98-7
ethyl 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetate

: 1363808-47-2
4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(4-methylphenylsulfonyl)-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / methanol / 4.08 h / 1 - 2 °C

2.1: toluene / 2 h / 50 °C / 100 Torr / Inert atmosphere

3.1: potassium carbonate / toluene / 24 h / 5 °C

4.1: hydrogen / 5%-palladium/activated carbon / 1,2-dimethoxyethane / 8 h / 20 °C

5.1: toluene / 7.5 h / 45 - 60 °C / 100 - 120 Torr

6.1: methanol; lithium hydroxide monohydrate / toluene / 20 h / 0 - 5 °C

6.2: pH 1

With methanol; lithium hydroxide monohydrate; hydrogen; potassium carbonate; hydrazine hydrate; 5%-palladium/activated carbon; In methanol; 1,2-dimethoxyethane; toluene;