((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate

Base Information

Chemical Name:((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate
CAS No.:1361215-49-7
Molecular Formula:C₁₉H₂₃F₃N₂O₆S₃
Molecular Weight:528.595
Hs Code.:

Synonyms:((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate

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Chemical Property of ((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate

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Technology Process of ((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate

There total 7 articles about ((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361215-54-4
1,1,1-trifluoro-2-(4-((2R)-2-(hydroxymethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

: 124-63-0
methanesulfonyl chloride

: 1361215-49-7
((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 1361215-49-7
((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether; hexanes / 0.25 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium t-butanolate / ruphos; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct / toluene / 12 h / 65 °C / sealed vessel; Inert atmosphere

3.1: boron trichloride / dichloromethane / 0.67 h / 0 °C

4.1: triethylamine / dichloromethane / 0 °C

With n-butyllithium; boron trichloride; triethylamine; sodium t-butanolate; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct; ruphos; In hexanes; diethyl ether; dichloromethane; toluene;

Reference yield:

: 1361215-52-2
(3R)-3-((benzyloxy)methyl)-1-(2-thiophenylsulfonyl)piperazine

: 1361215-49-7
((2R)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-phenyl)-2-piperazinyl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / ruphos; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct / toluene / 12 h / 65 °C / sealed vessel; Inert atmosphere

2: boron trichloride / dichloromethane / 0.67 h / 0 °C

3: triethylamine / dichloromethane / 0 °C

With boron trichloride; triethylamine; sodium t-butanolate; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct; ruphos; In dichloromethane; toluene;