1-(2-trimethylsilylethynyl)-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine

Base Information

Chemical Name:1-(2-trimethylsilylethynyl)-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine
CAS No.:1416673-19-2
Molecular Formula:C₃₄H₃₅BrN₂O₅Si
Molecular Weight:659.652
Hs Code.:

Synonyms:1-(2-trimethylsilylethynyl)-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine

Suppliers and Price of 1-(2-trimethylsilylethynyl)-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2-trimethylsilylethynyl)-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2-trimethylsilylethynyl)-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine

There total 2 articles about 1-(2-trimethylsilylethynyl)-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1416672-95-1
1-iodo-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine

: 1066-54-2
trimethylsilylacetylene

: 1416673-19-2
1-(2-trimethylsilylethynyl)-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In benzene; at 60 ℃; Inert atmosphere;
DOI:10.1134/S1070428012110103

Reference yield:

: 766550-46-3
C₂₉H₂₇BrN₂O₅

: 1416673-19-2
1-(2-trimethylsilylethynyl)-7α,8α-[N-(4-bromophenyl)-2,5-dioxopyrrolidino][3,4-h]-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide; trifluoroacetic acid / 2 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; triethylamine / benzene / 60 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; triethylamine; triphenylphosphine; trifluoroacetic acid; In benzene; 2: |Sonogashira Cross-Coupling;
DOI:10.1134/S1070428012110103