Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate

Base Information

• Chemical Name: Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate
• CAS No.: 934495-36-0
• Molecular Formula: C₁₄H₁₅F₃O₄
• Molecular Weight: 304.266
• Mol file: 934495-36-0.mol

Synonyms:Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate

Chemical Property of Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate

There total 1 articles about Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethoxy-5-(trifluoromethyl)benzoyl chloride (1140917-47-0) + ethyl potassium malonate (6148-64-7) → Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate (934495-36-0)

Guidance literature:

With triethylamine; magnesium chloride; In ethyl acetate; at 20 - 45 ℃;

Reference yield:

Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate (934495-36-0) + (S)-1-[4-(ethoxycarbonyl)phenyl]ethylhydrazine benzenesulfonate (934495-38-2) + trifluoromethylsulfonic anhydride (358-23-6) → Ethyl 4-[(1S)-1-(3-[2-ethoxy-5-(trifluoromethyl)phenyl]-5-{[(trifluoromethyl)sulfonyl]oxy}-1H-pyrazol-1-yl)ethyl]benzoate (934495-37-1)

Guidance literature:

Ethyl 3-[2-ethoxy-5-(trifluoromethyl)phenyl]-3-oxopropanoate; (S)-1-[4-(ethoxycarbonyl)phenyl]ethylhydrazine benzenesulfonate; In acetonitrile; at 80 ℃; for 10h;

trifluoromethylsulfonic anhydride; With triethylamine; In dichloromethane; at -78 - 20 ℃;

upstream raw materials:

2-ethoxy-5-(trifluoromethyl)benzoyl chloride

ethyl potassium malonate

Downstream raw materials:

Ethyl 4-[(1S)-1-(3-[2-ethoxy-5-(trifluoromethyl)phenyl]-5-{[(trifluoromethyl)sulfonyl]oxy}-1H-pyrazol-1-yl)ethyl]benzoate