4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester

Base Information

Chemical Name:4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester
CAS No.:906069-60-1
Molecular Formula:C₃₀H₄₅NO₅
Molecular Weight:499.691
Hs Code.:

4-{[1-(2-<i>tert</i>-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester

Synonyms:4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester

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Chemical Property of 4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester

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Technology Process of 4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester

There total 4 articles about 4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55666-43-8
tert-butyl 3-bromopropionate

: 906069-60-1
4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran; hexane / 2.5 h / -20 - 20 °C

1.2: 1.49 g / tetrahydrofuran; hexane / 2 h / 20 °C

2.1: LDA / tetrahydrofuran; hexane / 0.67 h / -65 °C

2.2: 1.05 g / tetrahydrofuran; hexane / 6 h / 20 °C

3.1: 91 percent / H₂ / Pd/C / ethanol / 6 h / 1551.44 Torr

4.1: N-methylmorpholine; HOBt; (1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / 100 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm060133g

Reference yield:

: 3400-45-1
cyclopentanecarboxylic acid

: 906069-60-1
4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran; hexane / 2.5 h / -20 - 20 °C

1.2: 1.49 g / tetrahydrofuran; hexane / 2 h / 20 °C

2.1: LDA / tetrahydrofuran; hexane / 0.67 h / -65 °C

2.2: 1.05 g / tetrahydrofuran; hexane / 6 h / 20 °C

3.1: 91 percent / H₂ / Pd/C / ethanol / 6 h / 1551.44 Torr

4.1: N-methylmorpholine; HOBt; (1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / 100 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm060133g

Reference yield:

: 118756-03-9
1-[2-(tert-butoxycarbonyl)ethyl]-1-cyclopentanecarboxylic acid

: 906069-60-1
4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; hexane / 0.67 h / -65 °C

1.2: 1.05 g / tetrahydrofuran; hexane / 6 h / 20 °C

2.1: 91 percent / H₂ / Pd/C / ethanol / 6 h / 1551.44 Torr

3.1: N-methylmorpholine; HOBt; (1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / 100 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm060133g