55666-43-8

Basic information

• Product Name: T-BUTYL 3-BROMOPROPIONATE 97
• Synonyms: tert-Butyl 3-broMopropionate 97%;t-Butylbromopropinate;T-BUTYL 3-BROMOPROPIONATE 97;tert-Butyl3-bromopropionate;Nsc82471
• CAS NO: 55666-43-8
• Molecular Formula: C₇H₁₃BrO₂
• Molecular Weight: 209.08092
• Product Categories: C6 to C7;Carbonyl Compounds;Esters
• Mol File: 55666-43-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 30 °C0.2 mm Hg(lit.)
• Flash Point: 198 °F
• Appearance: /
• Density: 1.253 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.587mmHg at 25°C
• Refractive Index: n20/D 1.4470(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: T-BUTYL 3-BROMOPROPIONATE 97(CAS DataBase Reference)
• NIST Chemistry Reference: T-BUTYL 3-BROMOPROPIONATE 97(55666-43-8)
• EPA Substance Registry System: T-BUTYL 3-BROMOPROPIONATE 97(55666-43-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 55666-43-8(Hazardous Substances Data)

Usage

Uses

tert-Butyl 3-bromopropionate may be used to synthesize the following:tert-butyl-12-cholesteryloxi-4,7,10-trioxadodecanoate2-(tert-butoxycarbonyl)ethyl 2,3,4-tri-O-acetyl-1-thio-α-L-fucopyranoside

InChI:InChI=1/C7H13BrO2/c1-7(2,3)10-6(9)4-5-8/h4-5H2,1-3H3

Upstream product

• 59854-11-4 tert-butyl 3-hydroxypropanoate 
• 590-92-1 3-Bromopropionic acid 
• 75-65-0 tert-butyl alcohol 
• 540-88-5 acetic acid tert-butyl ester 
• 115-11-7 isobutene 

Downstream Products

• 142613-12-5 Tert-butyl 3-((p-methoxyphenyl)amino)propanoate 
• 203792-19-2 N-(tert-butyloxycarbonylethylene)-(D)-cyclohexylalanine benzyl ester 
• 757972-97-7 1-(2-tert-Butoxycarbonyl-ethyl)-cyclohexanecarboxylic acid 
• 733728-66-0 3-{4-[[(4-Amino-2,3,5,6-tetramethylanilino)-acetyl](methyl)amino]-1-piperidino}propionic acid 
• 1461-23-0 tributyltin bromide 
• 1021374-21-9 C₂₂H₃₅NO₆S 
• 142612-69-9 trans-3-carbomethoxy-4-((tert-butoxycarbonyl)methyl)-1-(p-methoxyphenyl)-2-azetidinone 
• 142612-69-9 cis-3-carbomethoxy-4-((tert-butoxycarbonyl)methyl)-1-(p-methoxyphenyl)-2-azetidinone 
• 142612-57-5 N-(2-tert-Butoxycarbonyl-ethyl)-2-diazo-N-(4-methoxy-phenyl)-malonamic acid methyl ester 
• 142613-19-2 N-(2-tert-Butoxycarbonyl-ethyl)-N-(4-methoxy-phenyl)-malonamic acid methyl ester 
• 906069-60-1 4-{[1-(2-tert-butoxycarbonyl-pentyl)-cyclopentanecarbonyl]-amino}-cyclohexanecarboxylic acid benzyl ester 
• 906069-96-3 2-{1-[5-(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-[1,3,4]oxadiazol-2-yl]-cyclopentylmethyl}-pentanoic acid tert-butyl ester 
• 906069-91-8 2-[1-(4-carbamoyl-cyclohexylcarbamoyl)-cyclopentylmethyl]-pentanoic acid tert-butyl ester 
• 906069-92-9 2-[1-(4-dimethylcarbamoyl-cyclohexylcarbamoyl)-cyclopentylmethyl]-pentanoic acid tert-butyl ester 

Relevant articles and documents

Fine-tuning water exchange on GdIII poly(amino carboxylates) by modulation of steric crowding

In the objective of optimizing water exchange rate on stable, nine-coordinate, monohydrated GdIII poly(amino carboxylate) complexes, we have prepared monopropionate derivatives of DOTA4- (DO3A-Nprop4-) and DTPA5- (DTTA-Nprop5-). A novel ligand, EPTPA-BAA3-, the bisamylamide derivative of ethylenepropylenetriaminepentaacetate (EPTPA5-) was also synthesized. A variable temperature 17O NMR study has been performed on their GdIII complexes, which, for [Gd(DTTA-Nprop)(H2O)] 2- and [Gd(EPTPA-BAA)(H2O)] has been combined with multiple field EPR and NMRD measurements. The water exchange rates, k ex298, are 8.0 × 107 s-1, 6.1 × 107 s-1 and 5.7 × 107 s -1 for [Gd(DTTA-Nprop)(H2O)]2-, [Gd(DO3A-Nprop)(H2O)]- and [Gd(EPTPA-BAA)(H 2O)], respectively, all in the narrow optimal range to attain maximum proton relaxivities, provided the other parameters (electronic relaxation and rotation) are also optimized. The substitution of an acetate with a propionate arm in DTPA5- or DOTA4- induces increased steric compression around the water binding site and thus leads to an accelerated water exchange on the GdIII complex. The kex values on the propionate complexes are, however, lower than those obtained for [Gd(EPTPA)(H2O)]2- and [Gd(TRITA)(H2O)] - which contain one additional CH2 unit in the amine backbone as compared to the parent [Gd(DTPA)(H2O)]2- and [Gd(DOTA)(H2O)]-. In addition to their optimal water exchange rate, [Gd(DTTA-Nprop)(H2O)]2- has, and [Gd(DO3A-Nprop)(H2O)]- is expected to have sufficient thermodynamic stability. These properties together make them prime candidates for the development of high relaxivity, macromolecular MRI contrast agents. The Royal Society of Chemistry 2005.

Thrombin inhibitors

Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.

Sulfonyl isatin compounds and methods of blocking apoptosis therewith

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