2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-bis(isobutylamino)[1,3,5]triazine

Base Information

• Chemical Name: 2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-bis(isobutylamino)[1,3,5]triazine
• CAS No.: 1319212-77-5
• Molecular Formula: C₂₃H₃₇N₇O₂
• Molecular Weight: 443.592
• Mol file: 1319212-77-5.mol

Synonyms:2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-bis(isobutylamino)[1,3,5]triazine

Chemical Property of 2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-bis(isobutylamino)[1,3,5]triazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-bis(isobutylamino)[1,3,5]triazine

There total 2 articles about 2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-bis(isobutylamino)[1,3,5]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-dichloro[1,3,5]triazine (1319212-76-4) + isobutylamine (78-81-9) → 2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-bis(isobutylamino)[1,3,5]triazine (1319212-77-5)

Guidance literature:

In 1,4-dioxane; at 80 ℃; Sealed tube;

DOI:10.1055/s-0030-1260047

Reference yield:

tert-butyl 2-aminobenzylcarbamate (162046-50-6) → 2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-bis(isobutylamino)[1,3,5]triazine (1319212-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C

2: 1,4-dioxane / 80 °C / Sealed tube

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;

DOI:10.1055/s-0030-1260047

Reference yield: 80.0%

2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-bis(isobutylamino)[1,3,5]triazine (1319212-77-5) → 2-[2-aminomethylphenylamino]-4,6-bis(isobutylamino)-[1,3,5]triazine (1319212-78-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1055/s-0030-1260047

upstream raw materials:

2-[(tert-butoxycarbonylaminomethyl)phenyl]amino-4,6-dichloro[1,3,5]triazine

isobutylamine

tert-butyl 2-aminobenzylcarbamate

Downstream raw materials:

2-[2-aminomethylphenylamino]-4,6-bis(isobutylamino)-[1,3,5]triazine