Prostaglandin E2 Ethanolamide

Base Information

Chemical Name:Prostaglandin E2 Ethanolamide
CAS No.:194935-38-1
Molecular Formula:C₂₂H₃₇NO₅
Molecular Weight:395.539
Hs Code.:
Nikkaji Number:J870.169E
Wikidata:Q76293798
Metabolomics Workbench ID:2493
ChEMBL ID:CHEMBL3398551
Mol file:194935-38-1.mol

Synonyms:dinoprostone ethanolamide;PGE(2) ethanolamide;PGE2 ethanolamide;prostaglandin E(2) ethanolamide;prostaglandin E2 ethanolamide;prostamide E2

Suppliers and Price of Prostaglandin E2 Ethanolamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ProstaglandinE2Ethanolamide-d4
100μg
$ 185.00

Cayman Chemical
Prostaglandin E2 Ethanolamide ≥98%
10mg
$ 364.00

Cayman Chemical
Prostaglandin E2 Ethanolamide ≥98%
5mg
$ 208.00

Cayman Chemical
Prostaglandin E2 Ethanolamide MaxSpec? Standard ≥95%
100μg
$ 56.00

Cayman Chemical
Prostaglandin E2 Ethanolamide ≥98%
1mg
$ 49.00

Cayman Chemical
Prostaglandin E2 Ethanolamide ≥98%
500μg
$ 26.00

Total 3 raw suppliers

Chemical Property of Prostaglandin E2 Ethanolamide

Chemical Property:

PSA：106.86000
LogP:2.66590
XLogP3:1.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:14
Exact Mass:395.26717328
Heavy Atom Count:28
Complexity:517

Purity/Quality:

98%Min ^*data from raw suppliers

ProstaglandinE2Ethanolamide-d4 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)NCCO)O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)NCCO)O)O
Description Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; ) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively). It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively). PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes. Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.
Uses Prostaglandin E2 Ethanolamide-d4 is the isotope labelled analogue of Prostaglandin E2 Ethanolamide, an analogue of Prostaglandin E2 (P838610). Prostaglandin E2 is most common and most biologically potent of mammalian prostaglandins.

Technology Process of Prostaglandin E2 Ethanolamide

There total 2 articles about Prostaglandin E2 Ethanolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 363-24-6
dinoprostone

: 141-43-5
ethanolamine

: 194935-38-1
Prostaglandin E2 ethanolamide

Guidance literature:: dinoprostone; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; at 20 ℃; for 0.25h;

ethanolamine; In water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1007/s13361-018-2051-6