1-benzenesulfonyl-7-chloro-4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-nitro-1H-pyrrolo[2,3-c]pyridine

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Chemical Name:1-benzenesulfonyl-7-chloro-4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-nitro-1H-pyrrolo[2,3-c]pyridine
CAS No.:1332837-62-3
Molecular Formula:C₂₁H₁₃Cl₃FN₃O₅S
Molecular Weight:544.775
Hs Code.:

Synonyms:1-benzenesulfonyl-7-chloro-4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-nitro-1H-pyrrolo[2,3-c]pyridine

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Chemical Property of 1-benzenesulfonyl-7-chloro-4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-nitro-1H-pyrrolo[2,3-c]pyridine

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Technology Process of 1-benzenesulfonyl-7-chloro-4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-nitro-1H-pyrrolo[2,3-c]pyridine

There total 5 articles about 1-benzenesulfonyl-7-chloro-4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-nitro-1H-pyrrolo[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 877397-65-4
(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

: 1332837-61-2
1-benzenesulfonyl-7-chloro-5-nitro-1H-pyrrolo[2,3-c]pyridin-4-ol

: 1332837-62-3
1-benzenesulfonyl-7-chloro-4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-nitro-1H-pyrrolo[2,3-c]pyridine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1332837-62-3
1-benzenesulfonyl-7-chloro-4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-nitro-1H-pyrrolo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / -5 - 10 °C

1.2: 1.33 h

2.1: bis(pinacol)diborane; potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Degassed

2.2: 4 h / 0 °C

3.1: toluene-4-sulfonic acid; nickel(II) nitrate hexahydrate / acetone / 2 h / Reflux

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

With nickel(II) nitrate hexahydrate; di-isopropyl azodicarboxylate; potassium acetate; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; bis(pinacol)diborane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; acetone; mineral oil; 4.1: Mitsunobu reaction;

Reference yield:

: 425380-38-7
4-bromo-7-chloro-3a,7a-dihydro-1H-pyrrolo[2,3-c]pyridine

: 1332837-62-3
1-benzenesulfonyl-7-chloro-4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-nitro-1H-pyrrolo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / -5 - 10 °C

1.2: 1.33 h

2.1: bis(pinacol)diborane; potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Degassed

2.2: 4 h / 0 °C

3.1: toluene-4-sulfonic acid; nickel(II) nitrate hexahydrate / acetone / 2 h / Reflux

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

With nickel(II) nitrate hexahydrate; di-isopropyl azodicarboxylate; potassium acetate; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; bis(pinacol)diborane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; acetone; mineral oil; 4.1: Mitsunobu reaction;