ethyl 1,4,5,6,7,8-hexahydro-1-methyl-5-oxo-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-quinolinecarboxylate

Base Information

• Chemical Name: ethyl 1,4,5,6,7,8-hexahydro-1-methyl-5-oxo-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-quinolinecarboxylate
• CAS No.: 107994-03-6
• Molecular Formula: C₂₇H₂₆F₃NO₃S
• Molecular Weight: 501.57

Synonyms:ethyl 1,4,5,6,7,8-hexahydro-1-methyl-5-oxo-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-quinolinecarboxylate

Chemical Property of ethyl 1,4,5,6,7,8-hexahydro-1-methyl-5-oxo-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-quinolinecarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 1,4,5,6,7,8-hexahydro-1-methyl-5-oxo-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-quinolinecarboxylate

There total 5 articles about ethyl 1,4,5,6,7,8-hexahydro-1-methyl-5-oxo-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2-chloroaceto)acetate (638-07-3) → ethyl 1,4,5,6,7,8-hexahydro-1-methyl-5-oxo-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-quinolinecarboxylate (107994-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / 4 h

2: 14 percent / ethanol / 18 h / Heating

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, a) RT, 16 h, b) 60 deg C, 4 h

With sodium hydride; triethylamine; In ethanol;

DOI:10.1021/jm00111a047

Reference yield:

2-Trifluoromethylbenzaldehyde (447-61-0) → ethyl 1,4,5,6,7,8-hexahydro-1-methyl-5-oxo-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-quinolinecarboxylate (107994-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 14 percent / ethanol / 18 h / Heating

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, a) RT, 16 h, b) 60 deg C, 4 h

With sodium hydride; In ethanol;

DOI:10.1021/jm00111a047

Reference yield:

ethyl 4-(phenylthio)-acetoacetate (25907-38-4) → ethyl 1,4,5,6,7,8-hexahydro-1-methyl-5-oxo-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-quinolinecarboxylate (107994-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 14 percent / ethanol / 18 h / Heating

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, a) RT, 16 h, b) 60 deg C, 4 h

With sodium hydride; In ethanol;

DOI:10.1021/jm00111a047

upstream raw materials:

5-Oxo-2-phenylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

methyl iodide

ethyl (2-chloroaceto)acetate

2-Trifluoromethylbenzaldehyde

Downstream raw materials:

2-Benzenesulfinylmethyl-1-methyl-5-oxo-4-(2-trifluoromethyl-phenyl)-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

2-Benzenesulfonylmethyl-1-methyl-5-oxo-4-(2-trifluoromethyl-phenyl)-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

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