1-(4-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 1-(4-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoline
• CAS No.: 49849-64-1
• Molecular Formula: C₁₇H₁₉NO₂S
• Molecular Weight: 301.409
• Mol file: 49849-64-1.mol

Synonyms:1-(4-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoline

Chemical Property of 1-(4-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoline

There total 9 articles about 1-(4-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

p-toluenesulfonyl chloride (98-59-9) + 1,2,3,4-tetrahydro-2-methylquinoline (1780-19-4) → 1-(4-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoline (49849-64-1)

Guidance literature:

With pyridine; at 25 - 80 ℃;

DOI:10.1016/j.bmc.2009.11.010

Reference yield: 69.0%

(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate (953395-36-3) → 1-(4-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoline (49849-64-1)

Guidance literature:

With mercury(II) trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1021/ol701737x

Reference yield: 53.0%

(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 4-pentynoate (953395-34-1) → 1-(4-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoline (49849-64-1)

Guidance literature:

With mercury(II) trifluoromethanesulfonate; In dichloromethane; for 2.5h; Heating;

DOI:10.1021/ol701737x

upstream raw materials:

(S)-2-methyl-1,2,3,4-tetrahydroquinoline

p-toluenesulfonyl chloride

(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 4-pentynoate

(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate