(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate

Base Information

Chemical Name:(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate
CAS No.:953395-36-3
Molecular Formula:C₂₆H₂₅NO₄S
Molecular Weight:447.555
Hs Code.:

Synonyms:(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate

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Chemical Property of (+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate

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Technology Process of (+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate

There total 3 articles about (+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 953395-33-0
C₁₇H₂₁NO₃S

: 33578-00-6
(2-ethynyl)benzoic acid

: 953395-36-3
(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol701737x

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 953395-36-3
(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

2: 69 percent / EDCI; 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ol701737x

Reference yield:

: 457622-20-7
4-(2-aminophenyl)-2-butanol

: 953395-36-3
(+/-)-4-(2-(4-methylphenylsulfonamido)phenyl)-2-butyl 2-ethynylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

2: 69 percent / EDCI; 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ol701737x