2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone

Base Information

• Chemical Name: 2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone
• CAS No.: 110841-22-0
• Molecular Formula: C₁₆H₁₅NO
• Molecular Weight: 237.301
• Mol file: 110841-22-0.mol

Synonyms:2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone

Chemical Property of 2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone

There total 9 articles about 2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-[2-(benzyl-methyl-amino)-1-phenyl-ethyl]-benzoic acid ethyl ester (865163-32-2) → 2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone (110841-22-0)

Guidance literature:

2-[2-(benzyl-methyl-amino)-1-phenyl-ethyl]-benzoic acid ethyl ester; With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; for 12h; under 2585.74 Torr;

With sodium acetate; In ethanol; at 50 ℃; for 12h;

DOI:10.1016/j.tetlet.2005.06.139

Reference yield: 75.0%

2-methyl-4-phenylisoquinolin-1(2H)-one (108960-88-9) → 2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone (110841-22-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; at 80 ℃; for 3h; under 4654.3 Torr;

DOI:10.1039/c39870000191

Reference yield:

N-diphenylphosphinoylmethyl-N-methyl-2-benzoylbenzamide (175857-53-1) → 2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone (110841-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / KHMDS / tetrahydrofuran / 1.) -78 deg C, 0.25 h, 2.) RT, 0.5 h

2: H₂ / 10percent Pd/C / methanol / 15 h / 80 °C / 15001.2 Torr

With hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/0040-4020(96)00092-0

upstream raw materials:

3-chloro-2-methyl-4-phenyl-3,4-dihydro-2H-isoquinolin-1-one

2-methyl-4-phenylisoquinolin-1(2H)-one

2-[2-(benzyl-methyl-amino)-1-phenyl-ethyl]-benzoic acid ethyl ester

N-diphenylphosphinoylmethyl-N-methyl-2-benzoylbenzamide

Downstream raw materials:

1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline