108960-88-9

Basic information

• Product Name: 2-methyl-4-phenylisoquinolin-1(2H)-one
• Synonyms: 2-methyl-4-phenylisoquinolin-1(2H)-one
• CAS NO: 108960-88-9
• Molecular Weight: 235.285
• Mol File: 108960-88-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-methyl-4-phenylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-phenylisoquinolin-1(2H)-one(108960-88-9)
• EPA Substance Registry System: 2-methyl-4-phenylisoquinolin-1(2H)-one(108960-88-9)

Safety Data

• Hazardous Substances Data: 108960-88-9(Hazardous Substances Data)

Upstream product

• 130831-47-9 3-chloro-2-methyl-4-phenyl-3,4-dihydro-2H-isoquinolin-1-one 
• 110841-24-2 3-Hydroxy-2-methyl-4-phenyl-3,4-dihydro-2H-isoquinolin-1-one 
• 113258-90-5 4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 21921-91-5 2-Benzyl-N-methyl-benzamid 
• 4594-71-2 N-methylisocarbostyril 
• 591-50-4 iodobenzene 
• 491-30-5 1-isoquinolone 
• 1298108-49-2 2-methyl-4-phenylisoquinolinium iodide 
• 62-53-3 aniline 
• 66003-76-7 Diphenyliodonium triflate 
• 100-52-7 benzaldehyde 
• 5398-11-8 3-phenylphthalide 
• 88070-48-8 N-methylbenzamide 
• 220474-74-8 α,α-dideutero-N-benzoylmethyl-2-iodo-N-methylbenzylamine 

Downstream Products

• 110841-22-0 2-methyl-4-phenyl-1,2,3,4-tetrahydro-1(2H)-isoquinolone 
• 113454-58-3 2-methyl-4-phenyl-1,2-dihydro-isoquinoline 
• 28102-51-4 1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline 

Relevant articles and documents

Synthesis of 4-Iodoisoquinolin-1(2 H)-ones by a Dirhodium(II)-Catalyzed 1,4-Bisfunctionalization of Isoquinolinium Iodide Salts

An efficient Rh2(II,II)-catalyzed reaction has been developed under mild conditions. This synthetic method proceeds through iodination/oxidation of readily available isoquinolinium iodide salts under aerobic conditions with good to excellent yields. 4-Iodoisoquinolin-1(2H)-ones are important building blocks for biologically and medicinally important compounds. The developed methodology was applied to the gram-scale synthesis of a key intermediate in the synthesis of the CRTH2 antagonist CRA-680.

Catalyst Controlled Divergent C4/C8 Site-Selective C-H Arylation of Isoquinolones

The catalyst-controlled C4/C8 site-selective C-H arylation of isoquinolones using aryliodonium salts as the coupling partners was developed. The C4-selective arylation was successfully achieved via an electrophilic palladation pathway. A completely differ

Stereoselective intermolecular hydride shift mechanism of the new reduction of benzylic alcohols with acid

A stereoselective intermolecular hydride shift mechanism of the new reduction reaction of the benzylic hydroxy group of 4-hydroxy-4-phenyl-1,2,3,4-tetrahydroisoquinoline (1) to the corresponding alkane (2) with acid was proved by reaction of the deuterated derivatives (5 and 6) of 1.