(E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester
CAS No.:1232886-53-1
Molecular Formula:C₂₈H₂₉NO₃
Molecular Weight:427.543
Hs Code.:

Synonyms:(E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester

Suppliers and Price of (E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester

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Technology Process of (E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester

There total 4 articles about (E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 496858-32-3
methyl E-3-(3’-adamantan-1-yl-4’-hydroxybiphenyl-4-yl) acrylate

: 590-17-0
cyanomethyl bromide

: 1232886-53-1
(E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 29558-77-8
4-bromo-4'-hydroxybiphenyl

: 1232886-53-1
(E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sulfuric acid / 96 h / 20 °C

2: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 4 h / 50 - 110 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With sulfuric acid; palladium diacetate; potassium carbonate; acetic acid; triethylamine; tris-(o-tolyl)phosphine; potassium iodide; In N,N-dimethyl-formamide; 2: |Heck Reaction;
DOI:10.1016/j.ejmech.2014.04.021

Reference yield:

: 496868-80-5
4-(4'-bromophenyl)-2-(adamantan-1-yl)phenol

: 1232886-53-1
(E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 4 h / 50 - 110 °C

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; potassium iodide; In N,N-dimethyl-formamide; 1: |Heck Reaction;
DOI:10.1016/j.ejmech.2014.04.021