1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester

Base Information

• Chemical Name: 1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester
• CAS No.: 331951-69-0
• Molecular Formula: C₂₂H₂₉NO₅
• Molecular Weight: 387.476
• Mol file: 331951-69-0.mol

Synonyms:1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester

Chemical Property of 1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester

There total 4 articles about 1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl chloroformate (501-53-1,94274-21-2) + 1-oxo-2-aza-spiro[4.5]decane-3-carboxylic acid tert-butyl ester (331951-68-9) → 1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester (331951-69-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0040-4020(00)01008-5

Reference yield:

(S)-1-Oxo-2-aza-spiro[4.5]deca-6,9-diene-3-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester (160350-16-3) → 1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester (331951-69-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / H₂ / 10 percent Pd-C / methanol / 12 h

2: 86 percent / 2N LiOH / methanol / 2 h

3: 80 percent / 70 percent HClO₄ / 24 h

4: 94 percent / NaH / tetrahydrofuran

With lithium hydroxide; perchloric acid; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4020(00)01008-5

Reference yield:

(S)-1-Oxo-2-aza-spiro[4.5]decane-3-carboxylic acid (331951-85-0) → 1-oxo-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester (331951-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 70 percent HClO₄ / 24 h

2: 94 percent / NaH / tetrahydrofuran

With perchloric acid; sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0040-4020(00)01008-5

upstream raw materials:

benzyl chloroformate

1-oxo-2-aza-spiro[4.5]decane-3-carboxylic acid tert-butyl ester

(S)-1-Oxo-2-aza-spiro[4.5]deca-6,9-diene-3-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

(S)-1-Oxo-2-aza-spiro[4.5]decane-3-carboxylic acid

Downstream raw materials:

(1R,3S)-1-(2-Oxo-ethyl)-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester

1-allyl-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester

(1S,3S)-1-(2-Hydroxy-ethyl)-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester

(1R,3S)-1-(2-Hydroxy-ethyl)-2-aza-spiro[4.5]decane-2,3-dicarboxylic acid 2-benzyl ester 3-tert-butyl ester