2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone

Base Information

Chemical Name:2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone
CAS No.:859157-83-8
Molecular Formula:C₂₇H₂₅ClN₂O₄S
Molecular Weight:509.025
Hs Code.:

2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-<i>p</i>-tolyl-oxazol-4-yl)-ethanone

Synonyms:2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone

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Chemical Property of 2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone

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Technology Process of 2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone

There total 4 articles about 2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 859157-81-6
1-(5-chloro-2-methyl-thiophen-3-yl)-2-(4-methoxy-phenylamino)-ethanone

: 2-bromo-1-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]-1-ethanone

: 859157-83-8
2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone

Guidance literature:: With sodium carbonate; In ethanol; for 4h; Heating;
DOI:10.1021/jo050236r

Reference yield:

: 17249-82-0
2-chloro-5-methylthiophene

: 859157-83-8
2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂

2: Br₂ / CHCl₃

3: 88 percent / Na₂CO₃ / aq. ethanol / 4 h / Heating

4: 78 percent / Na₂CO₃ / aq. ethanol / 4 h / Heating

With bromine; sodium carbonate; In ethanol; dichloromethane; chloroform;
DOI:10.1021/jo050236r

Reference yield:

: 98550-85-7
1-(5-chloro-2-methylthiophen-3-yl)ethanone

: 859157-83-8
2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂ / CHCl₃

2: 88 percent / Na₂CO₃ / aq. ethanol / 4 h / Heating

3: 78 percent / Na₂CO₃ / aq. ethanol / 4 h / Heating

With bromine; sodium carbonate; In ethanol; chloroform;
DOI:10.1021/jo050236r