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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-(5-Chloro-2-methylthiophen-3-yl)ethanone is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its role in these industries is crucial for the development of new drugs and agricultural products, contributing to advancements in healthcare and agriculture.
Used in the Food Industry:
As a flavoring agent, 1-(5-Chloro-2-methylthiophen-3-yl)ethanone enhances the taste and aroma of certain food products, providing a more enjoyable sensory experience for consumers.
Used in Cosmetics and Personal Care Products:
1-(5-Chloro-2-methylthiophen-3-yl)ethanone serves as a preservative in cosmetics and personal care products due to its antimicrobial and antioxidant properties. It helps to extend the shelf life of these products and maintain their quality over time.
Used in Antimicrobial Applications:
1-(5-Chloro-2-methylthiophen-3-yl)ethanone's antimicrobial properties make it a valuable component in various applications where controlling the growth of microorganisms is essential, such as in the medical and food storage industries.
Used in Antioxidant Applications:
Its antioxidant properties also make 1-(5-Chloro-2-methylthiophen-3-yl)ethanone useful in applications where protection against oxidative damage is needed, such as in the manufacturing of plastics and other materials that are susceptible to degradation.

Upstream product

• 17249-82-0 2-chloro-5-methylthiophene 
• 108-24-7 acetic anhydride 
• 554-14-3 2-Methylthiophene 
• 75-36-5 acetyl chloride 

Downstream Products

• 1412912-83-4 C₂₂H₂₀Cl₂O₃S₂ 
• 1412912-82-3 C₂₅H₂₁Cl₂NO₃S₂ 
• 1412912-84-5 C₂₀H₁₇Cl₂NO₂S₂ 
• 566143-74-6 1-(5-chloro-2-methyl-thiophen-3-yl)-2-[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethylsulfanyl]-ethanone 
• 859157-83-8 2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-1-(5-methyl-2-p-tolyl-oxazol-4-yl)-ethanone 
• 859157-76-9 1-(5-chloro-2-methyl-thiophen-3-yl)-2-[[2-(5-chloro-2-methyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-ethanone 
• 859157-82-7 1-(5-chloro-2-methyl-thiophen-3-yl)-2-[[2-(2,5-dimethyl-thiophen-3-yl)-2-oxo-ethyl]-(4-methoxy-phenyl)-amino]-ethanone 
• 859157-70-3 3,4-bis-(5-chloro-2-methyl-thiophen-3-yl)-1-(4-methoxy-phenyl)-2,5-dihydro-1H-pyrrole 
• 859157-81-6 1-(5-chloro-2-methyl-thiophen-3-yl)-2-(4-methoxy-phenylamino)-ethanone 

Relevant academic research and scientific papers

Chromo-pharmacophores: Photochromic diarylmaleimide inhibitors for sirtuins

Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases. Therefore structural elements of 3,4-bisindoylmaleimides (BIMs), which are known NAD+-dependent histone deacetylase (sirtuin) inhibitors, were merged with photochromic diarylmaleimides to yield photoswitchable enzyme inhibitors. The new inhibitors show excellent photophysical properties, are switchable even in polar solvents, and subtype selective against hSirt2. The inhibitory activity changes up to a factor of 22 for the two photoisomers and physiological properties can therefore be effectively toggled by irradiation with light of different wavelengths. Docking experiments using the enzyme crystal structure explain the observed activity changes based on the steric demand of the thiophene substitution and the rigidity of the molecular structure. This journal is

A novel photochromic fulgide based on porphyrin for nondestructive information processing

A fulgide connected to porphyrin (FUL-TPP) can transform its open isomer to closed isomer upon the irradiation with UV or visible light. Herein, they can be used to write binary data. Furthermore, the open form can emit luminescence but the closed cannot form while irradiated in another light that will not cause the optical chemical reaction. Therefore, the data can be read out without destruction.

Directed synthesis of new spiro-fused photochromes of diarylethene series

[MediaObject not available: see fulltext.] The reaction of tetracyanoethylated 1,2-diarylethanones with morpholine was used for directed synthesis of spiro-fused diarylethenes, 8-amino-1-imino(oxo)-6-morpholino-2-oxa-7-azaspiro[4.4]nona-3,6,8-triene-9-carbonitriles. The intermediates in this process were tetracyanoalkanone salts. The formation of spiranes was sensitive to the nature of aromatic substituents at the carbonyl group of 3,4-diaryl-4-oxobutane-1,1,2,2-tetracarbonitriles. The obtained spiro-fused diarylethenes exhibited photochromic properties.

Study on photochromism of diarylethenes with a 2,5-dihydropyrrole bridging unit: A convenient preparation of 3,4-diarylpyrroles from 3,4-diaryl-2,5- dihydropyrroles

Symmetric and nonsymmetric diarylethenes with a 2,5-dihydropyrrole bridging unit have been prepared, and the photochromic properties are investigated. Both symmetric and nonsymmetric diarylethenes with 2,5-dihydropyrrole bridging units undergo reversible ring-opening and ring-closing photoisomerization reactions in nonpolar solvents with UV/vis light, and some of them exhibit good fatigue resistance and no marked degradation detected after 10 cycles via an on/off switch. In polar solvents, however, photochromic diarylethenes with 2,5-dihydropyrrole bridging units produce 3,4-diarylpyrrole derivatives instead of the ring-closing isomer of diarylethenes with UV light irradiation. A class of N-substituted 3,4-diphenylethenes with 2,5-dihydropyrrole bridging units were prepared and used as templates to investigate the conversion reactions. The mechanism of photoconversion of 3,4-diaryl-2,5-dihydropyrroles to 3,4-diarylpyrroles was explored as well.

Synthesis and photochromic properties of functional diarylethene with a 2,5-dihydrothiophene bridging unit

(Matrix presented) A novel synthetic route to symmetric and nonsymmetric dithienylethene derivatives with a 2,5-dihydrothiophene bridging unit was described. A class of new functional photochromic compounds was prepared and showed photochromic properties similar to those of known diarylethenes.