[2-(4-bromo-2-fluorobenzylthiocarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester

Base Information

Chemical Name:[2-(4-bromo-2-fluorobenzylthiocarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester
CAS No.:314298-21-0
Molecular Formula:C₁₉H₁₈BrF₂NO₃S
Molecular Weight:458.324
Hs Code.:

Synonyms:[2-(4-bromo-2-fluorobenzylthiocarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester

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Chemical Property of [2-(4-bromo-2-fluorobenzylthiocarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester

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Technology Process of [2-(4-bromo-2-fluorobenzylthiocarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester

There total 10 articles about [2-(4-bromo-2-fluorobenzylthiocarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 314298-20-9
[2-(4-bromo-2-fluorobenzylcarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester

: 314298-21-0
[2-(4-bromo-2-fluorobenzylthiocarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester

Guidance literature:: With pyridine; phosphorous (V) sulfide; at 115 ℃; for 3h;
DOI:10.1016/j.bmc.2004.07.062

Reference yield:

: 106579-00-4
5-methoxy-2-methyl-4-nitroaniline

: 314298-21-0
[2-(4-bromo-2-fluorobenzylthiocarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 76 percent / pyridine; HF-pyridine; sodium nitrite / -70 - 60 °C

2: 99 percent / H₂ / Pd-C / ethanol / 760 Torr

3: 47 percent / aq. HBr; sodium nitrite; CuBr / 2.5 h / 110 °C

4: 86 percent / dimethylformamide / 20 h / 160 °C

5: 96 percent Turnov_. / aq. NaOH / 19 h / 90 °C

6: oxalyl chloride; DMF / CH₂Cl₂ / 0.5 h / 0 - 20 °C

7: diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

8: 73 percent / aq. HBr; acetic acid / 3.5 h / 120 °C

9: 93 percent / aq. K₂CO₃ / acetone / 2.5 h / 50 °C

10: 89 percent / phosphorous pentasulfide; pyridine / 3 h / 115 °C

With pyridine; sodium hydroxide; oxalyl dichloride; hydrogen bromide; hydrogen; phosphorous (V) sulfide; potassium carbonate; pyridine hydrogenfluoride; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; copper(I) bromide; sodium nitrite; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2004.07.062

Reference yield:

: 314298-13-0
1-fluoro-5-methoxy-2-methyl-4-nitro-benzene

: 314298-21-0
[2-(4-bromo-2-fluorobenzylthiocarbamoyl)-5-fluoro-4-methyl-phenoxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 99 percent / H₂ / Pd-C / ethanol / 760 Torr

2: 47 percent / aq. HBr; sodium nitrite; CuBr / 2.5 h / 110 °C

3: 86 percent / dimethylformamide / 20 h / 160 °C

4: 96 percent Turnov_. / aq. NaOH / 19 h / 90 °C

5: oxalyl chloride; DMF / CH₂Cl₂ / 0.5 h / 0 - 20 °C

6: diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

7: 73 percent / aq. HBr; acetic acid / 3.5 h / 120 °C

8: 93 percent / aq. K₂CO₃ / acetone / 2.5 h / 50 °C

9: 89 percent / phosphorous pentasulfide; pyridine / 3 h / 115 °C

With pyridine; sodium hydroxide; oxalyl dichloride; hydrogen bromide; hydrogen; phosphorous (V) sulfide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; copper(I) bromide; sodium nitrite; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2004.07.062