(2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine

Base Information

Chemical Name:(2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine
CAS No.:1272660-77-1
Molecular Formula:C₂₆H₃₃N₃O₄
Molecular Weight:451.566
Hs Code.:

Synonyms:(2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine

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Chemical Property of (2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine

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Technology Process of (2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine

There total 2 articles about (2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 849919-57-9
(2RS)-2-benzyl-1-benzyloxycarbonyl-2-carboxylazetidine

: (S)-1-(isobutylamino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate

: 1272660-77-1
(2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine

: 1272660-76-0
(2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2010.12.052

Reference yield:

: 557788-09-7
N-(tert-butoxycarbonyl)-(L)-alanine isobutylamide

: 1272660-77-1
(2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine

: 1272660-76-0
(2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-isobutylcarbamoyl)ethyl]carbamoylazetidine

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 4 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2010.12.052