849919-57-9

Usage

Class

Carboxylic acid esters

Pharmaceutical Use

Chiral building block for the synthesis of various drugs and pharmaceuticals

Therapeutic Effects

Potential treatment for chronic pain and depression

Cognitive Function

Shown to improve cognitive function and memory

Precautions

Careful monitoring due to potential adverse effects and interactions with other medications

Applications

Wide range of potential applications in the pharmaceutical field

Upstream product

• 501-53-1 benzyl chloroformate 
• 849919-56-8 (2RS)-2-benzyl-1-benzyloxycarbonyl-2-metoxycarbonylazetidine 

Downstream Products

• 849919-50-2 2-benzyl-2-(1-tert-butoxycarbonyl-ethylcarbamoyl)-azetidine-1-carboxylic acid benzyl ester 
• 849919-51-3 2-Benzyl-2-((S)-1-methoxycarbonyl-ethylcarbamoyl)-azetidine-1-carboxylic acid benzyl ester 
• 942203-08-9 (2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[1'-(methylcarbamoyl)ethyl]carbamoylazetidine 
• 849919-52-4 2-Benzyl-2-((S)-1-carboxy-ethylcarbamoyl)-azetidine-1-carboxylic acid benzyl ester 
• 1272660-75-9 (2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-benzylcarbamoyl)ethyl]carbamoylazetidine 
• 1272660-74-8 (2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-benzylcarbamoyl)ethyl]carbamoylazetidine 
• 1272660-73-7 (2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-tert-butylcarbamoyl)ethyl]carbamoylazetidine 
• 1272660-72-6 (2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-tert-butylcarbamoyl)ethyl]carbamoylazetidine 
• 1272660-79-3 (2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-cyclohexylcarbamoyl)ethyl]carbamoyl azetidine 
• 1272660-78-2 (2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-cyclohexylcarbamoyl)ethyl]carbamoyl azetidine 
• 1272660-81-7 (2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-dimethylcarbamoyl)ethyl]carbamoyl azetidine 
• 1272660-80-6 (2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-dimethylcarbamoyl)ethyl]carbamoyl azetidine 
• 1272660-88-4 (2R,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-carbamoyl-2'-methyl)propyl]carbamoylazetidine 
• 1272660-87-3 (2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[(1'-carbamoyl-2'-methyl)propyl]carbamoylazetidine 

Relevant academic research and scientific papers

From 1-acyl-β-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors

Starting from the structure of known β-lactam covalent human cytomegalovirus (HCMV) protease inhibitors and from the knowledge of the residues implicated in the active site of this enzyme, we designed a series of phenylalanine-derived 2-azetidinones beari