3-(phenylMethoxy)-1,1-cyc...

Base Information

• Chemical Name: 3-(phenylMethoxy)-1,1-cyc...
• CAS No.: 869109-30-8
• Molecular Formula: C₁₉H₂₆O₅
• Molecular Weight: 334.412
• Hs Code.: 2918999090
• Mol file: 869109-30-8.mol

Synonyms:dipropan-2-yl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate

Chemical Property of 3-(phenylMethoxy)-1,1-cyc...

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-(Phenylmethoxy)-1,1-cyclobutanedicarboxylic acid, diisopropyl diester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(phenylMethoxy)-1,1-cyc...

There total 2 articles about 3-(phenylMethoxy)-1,1-cyc... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diisopropyl malonate (13195-64-7) + (2-bromo-1-bromomethylethoxymethyl)benzene (35995-55-2) → dipropan-2-yl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate (869109-30-8)

Guidance literature:

diisopropyl malonate; With sodium hydride; In N,N-dimethyl-formamide; at 140 ℃; Inert atmosphere;

(2-bromo-1-bromomethylethoxymethyl)benzene; In N,N-dimethyl-formamide; at 140 ℃; for 26h;

Reference yield:

2-O-benzylglycerol (14690-00-7) → dipropan-2-yl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate (869109-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 140 °C / Inert atmosphere

2.2: 26 h / 140 °C

With carbon tetrabromide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 68.0%

dipropan-2-yl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate (869109-30-8) → [3-benzyloxy-1-[dideuterio(hydroxy)methyl]cyclobutyl]-dideuterio-methanol

Guidance literature:

dipropan-2-yl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate; With lithium aluminium deuteride; In tetrahydrofuran; at 0 - 20 ℃; for 48h;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

upstream raw materials:

diisopropyl malonate

(2-bromo-1-bromomethylethoxymethyl)benzene

2-O-benzylglycerol

Downstream raw materials:

3-(benzyloxy)cyclobutane-1-carboxylic acid

dipropan-2-yl 3-hydroxycyclobutane-1,1-dicarboxylate

dipropan-2-yl 3-oxocyclobutane-1,1-dicarboxylate