Diisopropyl 3-hydroxycyclobutane-1,1-dicarboxylate

Base Information

• Chemical Name: Diisopropyl 3-hydroxycyclobutane-1,1-dicarboxylate
• CAS No.: 869109-31-9
• Molecular Formula: C12H20O5
• Molecular Weight: 244.2842
• Hs Code.: 2917200090
• Mol file: 869109-31-9.mol

Synonyms:Diisopropyl 3-hydroxycyclobutane-1,1-dicarboxylate;1,1-bis(propan-2-yl) 3-hydroxycyclobutane-1,1-dicarboxylate

Chemical Property of Diisopropyl 3-hydroxycyclobutane-1,1-dicarboxylate

Chemical Property:

• PSA: 72.83000
• LogP: 1.03070

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diisopropyl 3-hydroxycyclobutane-1,1-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diisopropyl 3-hydroxycyclobutane-1,1-dicarboxylate

There total 2 articles about Diisopropyl 3-hydroxycyclobutane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

dipropan-2-yl 3-oxocyclobutane-1,1-dicarboxylate (893724-10-2) → dipropan-2-yl 3-hydroxycyclobutane-1,1-dicarboxylate (869109-31-9)

Guidance literature:

With sodium tetrahydroborate; water; In tetrahydrofuran; at 0 - 5 ℃; for 1h;

DOI:10.1002/ejoc.202100804

Reference yield:

dipropan-2-yl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate (869109-30-8) → dipropan-2-yl 3-hydroxycyclobutane-1,1-dicarboxylate (869109-31-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield: 64.0%

dipropan-2-yl 3-hydroxycyclobutane-1,1-dicarboxylate (869109-31-9) → diisopropyl 3-fluorocyclobutane-1,1-dicarboxylate (1403767-29-2)

Guidance literature:

With morpholinosulfur trifluoride; In dichloromethane; at 0 - 20 ℃; for 40h;

DOI:10.1002/ejoc.202100804

upstream raw materials:

dipropan-2-yl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate

dipropan-2-yl 3-oxocyclobutane-1,1-dicarboxylate

Downstream raw materials:

dipropan-2-yl 3-oxocyclobutane-1,1-dicarboxylate

diisopropyl 3-fluorocyclobutane-1,1-dicarboxylate

Refernces

• 1、 -. "NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION". Page/Page column 44. . Retrieved 2015/02/25.