3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide

Base Information

Chemical Name:3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide
CAS No.:146349-32-8
Molecular Formula:C₂₁H₂₈N₄O₅
Molecular Weight:416.477
Hs Code.:

Synonyms:3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide

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Chemical Property of 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide

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Technology Process of 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide

There total 7 articles about 3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 146349-32-8
3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / H₂O; dioxane / 18 h / Ambient temperature

2: 1.) NaH / 1.) THF, 30 min, 2.) THF, a) 4 deg C, 4 h, b) RT, 12 h

3: 4 N HCl / dioxane / 1.5 h

4: Et₃N / tetrahydrofuran; dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

5: methanolic ammonia / 60 h / Ambient temperature

With hydrogenchloride; ammonia; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a010

Reference yield:

: 105414-01-5,102988-94-3
Cbz-L-Pro-OCO₂-i-Bu

: 146349-32-8
3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran; dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

2: methanolic ammonia / 60 h / Ambient temperature

With ammonia; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a010

Reference yield:

: 76944-95-1
tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate

: 146349-32-8
3(S)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, 30 min, 2.) THF, a) 4 deg C, 4 h, b) RT, 12 h

2: 4 N HCl / dioxane / 1.5 h

3: Et₃N / tetrahydrofuran; dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

4: methanolic ammonia / 60 h / Ambient temperature

With hydrogenchloride; ammonia; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a010